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Proceedings Paper

Dependences of erythrocytes aggregation and disaggregation parameters on suspension hematocrit: study by backscattering nephelometry
Author(s): Nikolai N. Firsov; Alexander V. Priezzhev; Olga M. Ryaboshapka; Igor V. Sirko; Marina G. Vyshlova
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Paper Abstract

The backscattering nephelometry technique is used to simultaneously obtain the aggregation and disaggregation parameters of erythrocytes in whole blood: characteristic times T1 of linear aggregates formation and T2 of network formation; hydrodynamic durability of aggregates (beta) , and the coefficient of deformability of erythrocytes D. We have previously shown that these parameters are sensitive to different diseases, external conditions and stimuli. Samples of blood have different values of hematocrit H. So we have studied dependences of parameters T1, T2, and (beta) on suspension hematocrit. The obtained results show that the values of T1 are inversely proportional to H2 for both blood of healthy donors and blood of patients suffering hereditary glomerulonephritis. With hematocrit growing towards 100% (H equals 1) these aggregation parameters asymptotically aspire to certain values which determine the natural limit of the aggregation rate. The decrease of hematocrit causes the intensification of shear-induced aggregation at shear rates up to 150 s-1.

Paper Details

Date Published: 2 January 1995
PDF: 7 pages
Proc. SPIE 2370, 5th International Conference on Laser Applications in Life Sciences, (2 January 1995); doi: 10.1117/12.197470
Show Author Affiliations
Nikolai N. Firsov, Russian State Medical Univ. (Russia)
Alexander V. Priezzhev, Moscow State Univ. (Russia)
Olga M. Ryaboshapka, Moscow State Univ. (Russia)
Igor V. Sirko, Russian State Medical Univ. (Russia)
Marina G. Vyshlova, Moscow State Univ. (Russia)

Published in SPIE Proceedings Vol. 2370:
5th International Conference on Laser Applications in Life Sciences
Pavel A. Apanasevich; Nikolai I. Koroteev; Sergei G. Kruglik; Victor N. Zadkov, Editor(s)

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