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Proceedings Paper

Biosensor technology for the detection of illegal drugs I: objectives, preparatory work, and drug enrichment
Author(s): Reinhold Hilpert; Florian Binder; Michael Grol; Klaus Hallermayer; Hans-Peter Josel; Christian Klein; Josef Maier; Helmut Oberpriller; Josef Ritter; Frieder W. Scheller
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Paper Abstract

In a joint project of Deutsche Aerospace, Boehringer Mannheim and the University of Potsdam portable devices for the detection of illegal drugs, based on biosensor technology, are being developed. The concept enrichment of the drug from the gas phase and detection by immunological means. This publication covers the description of our objectives, preparatory work and results concerning enrichment of drugs from the gas phase. Vapor pressures of cocaine and cannabinoids have been determined. A test gas generator has been constructed which allows for reproducible preparation of cocaine concentrations between 2 ng/l and 2 pg/l. Coupling of a thermodesorption unit with GC/MS has been established for reference analysis. As another analytical tool, an ELISA with a lower detection limit of about 0,5 pg cocaine/assay has been developed. Applying fleece-type adsorbers, enrichment factors for cocaine in the range of 105 have been realized. No significant interference was found with potentially disturbing substances.

Paper Details

Date Published: 6 October 1994
PDF: 8 pages
Proc. SPIE 2276, Cargo Inspection Technologies, (6 October 1994); doi: 10.1117/12.189162
Show Author Affiliations
Reinhold Hilpert, Deutsche Aerospace AG (Germany)
Florian Binder, Deutsche Aerospace AG (Germany)
Michael Grol, Boehringer Mannheim GmbH (Germany)
Klaus Hallermayer, Boehringer Mannheim GmbH (Germany)
Hans-Peter Josel, Boehringer Mannheim GmbH (Germany)
Christian Klein, Boehringer Mannheim GmbH (Germany)
Josef Maier, Boehringer Mannheim GmbH (Germany)
Helmut Oberpriller, Deutsche Aerospace AG (Germany)
Josef Ritter, Deutsche Aerospace AG (Germany)
Frieder W. Scheller, Univ. Potsdam (Germany)

Published in SPIE Proceedings Vol. 2276:
Cargo Inspection Technologies
Andre H. Lawrence, Editor(s)

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