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Proceedings Paper

Microjet-assisted dye-enhanced diode laser ablation of cartilaginous tissue
Author(s): John Pohl; Brent A. Bell; Massoud Motamedi; Christopher J. Frederickson; David B. Wallace; Donald J. Hayes; Daniel Cowan M.D.
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Paper Abstract

Recent studies have established clinical application of laser ablation of cartilaginous tissue. The goal of this study was to investigate removal of cartilaginous tissue using diode laser. To enhance the interaction of laser light with tissue, improve the ablation efficiency and localize the extent of laser-induced thermal damage in surrounding tissue, we studied the use of a novel delivery system developed by MicroFab Technologies to dispense a known amount of Indocyanine Green (ICG) with a high spatial resolution to alter the optical properties of the tissue in a controlled fashion. Canine intervertebral disks were harvested and used within eight hours after collection. One hundred forty nL of ICG was topically applied to both annulus and nucleus at the desired location with the MicroJet prior to each irradiation. Fiber catheters (600 micrometers ) were used and positioned to irradiate the tissue with a 0.8 mm spot size. Laser powers of 3 - 10 W (Diomed, 810 nm) were used to irradiate the tissue with ten pulses (200 - 500 msec). Discs not stained with ICG were irradiated as control samples. Efficient tissue ablation (80 - 300 micrometers /pulse) was observed using ICG to enhance light absorption and confine thermal damage while there was no observable ablation in control studied. The extent of tissue damage observed microscopically was limited to 50 - 100 micrometers . The diode laser/Microjet combination showed promise for applications involving removal of cartilaginous tissue. This procedure can be performed using a low power compact diode laser, is efficient, and potentially more economical compared to procedures using conventional lasers.

Paper Details

Date Published: 17 August 1994
PDF: 7 pages
Proc. SPIE 2134, Laser-Tissue Interaction V; and Ultraviolet Radiation Hazards, (17 August 1994); doi: 10.1117/12.182951
Show Author Affiliations
John Pohl, Univ. of Texas Medical Branch (United States)
Brent A. Bell, Univ. of Texas Medical Branch (United States)
Massoud Motamedi, Univ. of Texas Medical Branch (United States)
Christopher J. Frederickson, MicroFab Technologies (United States)
David B. Wallace, MicroFab Technologies (United States)
Donald J. Hayes, MicroFab Technologies (United States)
Daniel Cowan M.D., Univ. of Texas Medical Branch (United States)

Published in SPIE Proceedings Vol. 2134:
Laser-Tissue Interaction V; and Ultraviolet Radiation Hazards
Steven L. Jacques; David H. Sliney; Michael Belkin M.D., Editor(s)

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