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Proceedings Paper

Overview of a novel point of care instrument system for measuring whole blood Prothrombin time
Author(s): Greg P. Carpenter; T. Gary Neel; James R. Parker
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Paper Abstract

This paper describes a new diagnostic instrument which uses magnetic modulation of an optical signal to rapidly measure whole blood Prothrombin time. The new instrument improves diagnosing and level monitoring by allowing accurate, rapid, low cost near patient testing. The measurement system consists of five major components: a control system; a user interface, a disposable-strip laminate architecture with proprietary chemistry which interacts with a time-varying magnetic field and accelerates the coagulation reaction; an optical measurement module -- the optics assembly of the instrument contains a heater, electromagnet, dc magnet, and numerous reflective/transmissive radiometric sensor systems; and a calibration-instrument using a custom developed test device which accurately simulates the coagulation reaction's induced optical properties. The theory of operation of the coagulation assay system and optical measurement module is describe and typical data and performance metrics are presented. 6

Paper Details

Date Published: 21 July 1994
PDF: 9 pages
Proc. SPIE 2136, Biochemical Diagnostic Instrumentation, (21 July 1994); doi: 10.1117/12.180788
Show Author Affiliations
Greg P. Carpenter, Boehringer Mannheim Corp. (Germany)
T. Gary Neel, Boehringer Mannheim Corp. (Germany)
James R. Parker, Boehringer Mannheim Corp. (United States)

Published in SPIE Proceedings Vol. 2136:
Biochemical Diagnostic Instrumentation
Robert F. Bonner; Gerald E. Cohn; Thomas M. Laue; Alexander V. Priezzhev, Editor(s)

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