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Proceedings Paper

Long-term healing of photodynamic therapy: treatment of experimental intimal hyperplasia
Author(s): Glenn M. LaMuraglia M.D.; N. R. ChandraSekar M.D.; Thomas J. Flotte M.D.; Tayyaba Hasan
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Paper Abstract

A study was performed to determine whether intimal hyperplasia can be chronically inhibited and the artery wall integrity maintained after cells are depleted from the artery with photodynamic therapy. Utilizing chloroaluminum sulfonated phthalocyanine or saline for control, limited balloon injury of the common carotid artery was performed before irradiation with 675 mm laser light. Results demonstrated carotid inhibition of intimal hyperplasia in PDT treated arteries without aneurysm formation or artery dilatation. By 4 weeks there was reendothelialization of the intima of the PDT arteries and repopulation of the adventitia with myofibroblasts. This data was encouraging in that PDT can chronically inhibit intimal hyperplasia without precipitating a weakness in the arterial wall.

Paper Details

Date Published: 12 July 1994
PDF: 5 pages
Proc. SPIE 2130, Diagnostic and Therapeutic Cardiovascular Interventions IV, (12 July 1994); doi: 10.1117/12.179926
Show Author Affiliations
Glenn M. LaMuraglia M.D., Massachusetts General Hospital (United States)
N. R. ChandraSekar M.D., Massachusetts General Hospital (United States)
Thomas J. Flotte M.D., Massachusetts General Hospital (United States)
Tayyaba Hasan, Massachusetts General Hospital (United States)

Published in SPIE Proceedings Vol. 2130:
Diagnostic and Therapeutic Cardiovascular Interventions IV
George S. Abela M.D., Editor(s)

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