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Proceedings Paper

Temperatures associated with thermally induced red blood cell changes in tissues irradiated in vivo
Author(s): Sharon L. Thomsen M.D.; Jon A. Schwartz; Rachel Joseph; John Anthony Pearce; Brian Rae; Tom J. McMurray
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Paper Abstract

Photothermal coagulation and ablation lesions were produced in exposed livers of anesthetized rats with a cw Nd:YAG laser ((lambda) equals1064 nm; beam power 3.2 to 10 W; exposure times 3 to 10 s, and spot diameter, 0.7 to 1.9 mm). The surface temperatures produced by the irradiations were derived from IR camera images calibrated with temperature controlled black bodies present in the scene. Targetoid lesions with central white and outer red zones marked areas of surface and deep coagulation grossly. The animals were sacrificed 30 minutes after irradiation. The lesions and surrounding normal liver were collected for light microscopy. Microscopically, characteristic, thermally-induced red blood cell alterations were found in the white and red zones and at the boundaries separating them. The boundaries of the concentric surface zones were measured grossly from the lesion centers and compared to the thermal images to determine the temperatures associated with the red blood cell changes. The temperatures for the surface and deep morphologic isotherms defined by the white/red and red/normal boundaries of rat liver irradiated in vivo are 68+/- 5.0 degree(s)C and 55+/- 2.7 degree(s)C.

Paper Details

Date Published: 12 July 1994
PDF: 8 pages
Proc. SPIE 2130, Diagnostic and Therapeutic Cardiovascular Interventions IV, (12 July 1994); doi: 10.1117/12.179925
Show Author Affiliations
Sharon L. Thomsen M.D., Univ. of Texas M.D. Anderson Cancer Ctr. (United States)
Jon A. Schwartz, Univ. of Texas M.D. Anderson Cancer Ctr. (United States)
Rachel Joseph, Univ. of Texas M.D. Anderson Cancer Ctr. (United States)
John Anthony Pearce, Univ. of Texas/Austin (United States)
Brian Rae, Univ. of Texas/Austin (United States)
Tom J. McMurray, Univ. of Texas/Austin (United States)

Published in SPIE Proceedings Vol. 2130:
Diagnostic and Therapeutic Cardiovascular Interventions IV
George S. Abela M.D., Editor(s)

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