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Proceedings Paper

Advanced optics module for monitoring protein crystal growth in microgravity
Author(s): Alan D. Kathman; Tammy C. Cole; Mark E. Wells; Greg Jenkins; Stan Koszelak; Alexander McPherson
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Paper Abstract

Understanding the phenomena of protein crystal growth has become a critical factor in the advancement of fundamental life sciences. To characterize this process, sensitive non-intrusive monitoring systems must be utilized in a micro-gravity environment. We believe detailed optical monitoring to be the superior technique for use in micro-gravity. The proposed approach includes monitoring the nucleation event, rate and form of crystal growth, and protein density variations throughout the cell volume with four different optical metrology methods running concurrently. The system will incorporate photon correlation spectroscopy, interferometry, Zernike phase contrast imagery, and high-resolution polarization microscopy. These four systems have all been combined into a single optical module that provides crystal growth process data. The module utilizes the emerging technologies of binary optics and solid optics to shrink and stabilize the system (patent-pending).

Paper Details

Date Published: 8 June 1994
PDF: 8 pages
Proc. SPIE 2214, Space Instrumentation and Dual-Use Technologies, (8 June 1994); doi: 10.1117/12.177668
Show Author Affiliations
Alan D. Kathman, Teledyne Brown Engineering (United States)
Tammy C. Cole, Teledyne Brown Engineering (United States)
Mark E. Wells, Teledyne Brown Engineering (United States)
Greg Jenkins, Teledyne Brown Engineering (United States)
Stan Koszelak, Univ. of California/Riverside (United States)
Alexander McPherson, Univ. of California/Riverside (United States)

Published in SPIE Proceedings Vol. 2214:
Space Instrumentation and Dual-Use Technologies
Firooz A. Allahdadi; Michael Chrisp; Concetto R. Giuliano; W. Pete Latham; James F. Shanley, Editor(s)

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