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Proceedings Paper

Synthetic approaches to long-wavelength-absorbing photosensitizers: porphyrinone and derivatives
Author(s): Chi Kwong Chang; Chariklia Sotiriou; Weishih Wu
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Paper Abstract

There has been considerable interest in the development of photosensitizers having increased absorption in the red or near infrared region for PDT applications. It is known that porphyrin absorptions can be shifted to longer wavelengths by expanding the n-conjugation of the macrocycle and by introducing electron-withdrawing groups at the ring. This principle has been applied to a number of porphyrinone (oxochlorin), porphyrintriones (dioxobacteriochlorins and dioxoisobacteriochlorins), as well as a porphyrintrione. The oxo group in this class of compounds has been transformed into sulfido-, imino, and methide derivatives, i.e., the ring system contains at least one exocyclic double bond connected to S, N-CN, and C(CN)2 using suitable reaction conditions. Many of these compounds exhibit absorption maxima longer than 700 nm, some even in the 800 nm region. Since the porphyrinones are generally photodynamically active to in vitro cells, they are attractive for PDT drug use.

Paper Details

Date Published: 1 July 1990
PDF: 6 pages
Proc. SPIE 1203, Photodynamic Therapy: Mechanisms II, (1 July 1990); doi: 10.1117/12.17673
Show Author Affiliations
Chi Kwong Chang, Michigan State Univ. (United States)
Chariklia Sotiriou, Michigan State Univ. (United States)
Weishih Wu, Michigan State Univ. (United States)

Published in SPIE Proceedings Vol. 1203:
Photodynamic Therapy: Mechanisms II
Thomas J. Dougherty, Editor(s)

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