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Proceedings Paper

In-vivo photodynamic therapy dosimeter
Author(s): J. Brian Dunn; P. Cusimano; Daniel R. Doiron; Charles J. Gomer; A. Edward Profio
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Paper Abstract

A fiberoptic isotropic probe system has been developed to measure both the Space Irradiance (SI) and Fluorescence (F) within tissue during Photodynamic Therapy (PDT). The probe is 0.8mm in diameter. The system has a SI sensitivity of 0.1 mW/cm2 and a F sensitivity of 0.1 microgram per milliliter of DHE in a tissue phantom solution. It also provides for the time integrated SI and F and a ratio of the F to SI. A biological response study is being undertaken using DHE to determine the correlation of therapeutic response with drug dose, light dose, integrated space irradiance, and integrated fluorescence in a standardized animal tumor model. Description of the device and its performance will be presented along with preliminary results of animal tumor model studies.

Paper Details

Date Published: 1 July 1990
PDF: 11 pages
Proc. SPIE 1203, Photodynamic Therapy: Mechanisms II, (1 July 1990); doi: 10.1117/12.17648
Show Author Affiliations
J. Brian Dunn, LaserTherapeutics, Inc. (United States)
P. Cusimano, LaserTherapeutics, Inc. (United States)
Daniel R. Doiron, LaserTherapeutics, Inc. (United States)
Charles J. Gomer, Childrens Hospital of Los Angeles and Univ. of Southern California School of Medicine (United States)
A. Edward Profio, Univ. of California/Santa Barbara (United States)

Published in SPIE Proceedings Vol. 1203:
Photodynamic Therapy: Mechanisms II
Thomas J. Dougherty, Editor(s)

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