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Proceedings Paper

In-vitro laser-induced fluorescence studies of breast tumors following low-dose injection of Photofrin
Author(s): Ingrid Wang; Stefan Andersson-Engels; Ingrid Idvall; Christian Ingvar; Katarina Svanberg M.D.
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Paper Abstract

A study in order to investigate the uptake of porphyrins in neoplasias in the female breast tissue and to evaluate the potential of fluorescence diagnostics for tumor demarcation was performed. Six women with positive mammography and cytological biopsies took part in the study. The patients were given Photofrin intravenously in a low dose of 0.35 mg/kg b.w. 24 hours before the planned surgical procedure. Immediately after surgery the pathological specimen were investigated with fluorescence spectroscopy following 405 nm laser excitation. Afterwards the investigated tissue sample was taken for histological preparation. The spectroscopic results were correlated with the histopathological diagnoses. The study shows a good demarcation between invasive or in situ cancerous tissue and the surrounding breast tissue, based on fluorescence data.

Paper Details

Date Published: 19 May 1994
PDF: 8 pages
Proc. SPIE 2135, Advances in Laser and Light Spectroscopy to Diagnose Cancer and Other Diseases, (19 May 1994); doi: 10.1117/12.176006
Show Author Affiliations
Ingrid Wang, Lund Univ. Hospital (Sweden)
Stefan Andersson-Engels, Lund Institute of Technology (Sweden)
Ingrid Idvall, Lund Univ. Hospital (Sweden)
Christian Ingvar, Lund Univ. Hospital (Sweden)
Katarina Svanberg M.D., Lund Univ. Hospital (Sweden)

Published in SPIE Proceedings Vol. 2135:
Advances in Laser and Light Spectroscopy to Diagnose Cancer and Other Diseases
Robert R. Alfano, Editor(s)

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