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Proceedings Paper

Central nervous system transplantation benefited by low-level laser irradiation
Author(s): S. Rochkind; Rachel Lubart; Yoram Wollman; Rabi Simantov; Moshe Nissan; Lilian Barr-Nea
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Paper Abstract

Effect of low-level laser irradiation on the central nervous system transplantation is reported. Ernbryonal brain allografts were transplanted into the brain of 20 adult rats and peripheral nerve graft transplanted into the severely injured spinal cord of 16 dogs. The operated wound of 10 rats and 8 dogs were exposed daily for 21 days to lowpower laser irradiation CW HeNe laser (35 mW, 632.8 run, energy density of 30 J/cm2 at each point for rats and 70 J/cm2 at each point for dogs). This study shows that (i) the low-level laser irradiation prevents extensive glial scar formation (a limiting factor in CNS regeneration) between embryonal transplants and host brain; (ii) Dogs made paraplegic by spinal cord injury were able to walk 3-6 months later. Recovery of these dogs was effected by the implantation of a fragment of autologous sciatic nerve at the site of injury and subsequently exposing the dogs to low-level laser irradiation. The effect of laser irradiation on the embryonal nerve cells grown in tissue culture was also observed. We found that low-level laser irradiation induced intensive migration of neurites outward of the aggregates 15-22 The results of the present study and our previous investigations suggest that low-level laser irradiation is a novel tool for treatment of peripheral and central nervous system injuries.

Paper Details

Date Published: 1 June 1990
PDF: 12 pages
Proc. SPIE 1200, Laser Surgery: Advanced Characterization, Therapeutics, and Systems II, (1 June 1990); doi: 10.1117/12.17472
Show Author Affiliations
S. Rochkind, Tel-Aviv Sourasky Medical Ctr. (Israel)
Rachel Lubart, Bar Ilan Univ. (Israel)
Yoram Wollman, Tel-Aviv Sourasky Medical Ctr. (Israel)
Rabi Simantov, Weizmann Institute of Science (Israel)
Moshe Nissan, Technion--Israel Institute of Technology (Israel)
Lilian Barr-Nea, Tel-Aviv Univ. (Israel)

Published in SPIE Proceedings Vol. 1200:
Laser Surgery: Advanced Characterization, Therapeutics, and Systems II
Stephen N. Joffe M.D.; Kazuhiko Atsumi M.D., Editor(s)

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