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Proceedings Paper

Cellular automaton model of proliferation of a human breast cancer cell line
Author(s): Jacqueline Palmari; Jean Yves Andre; Pierre-Marie Martin; Christophe Dussert
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Paper Abstract

A cellular automation is described which mimics cell population proliferation by replacing the site values by the age and the cycle phase of cells. The model described in this paper takes into account the size of the cells. The model is used to simulate the cell proliferation of the human breast cancer cell line MCF-7. The initial configuration of the cellular automaton is obtained from the discretization of the experimental data obtained from a light microscopic image analysis at 1 day of culture. After each day of proliferation the pattern obtained from the simulation is compared with the experimental result of the image analysis. The comparison is made from a topographical point of view through the concept of minimal spanning tree graph.

Paper Details

Date Published: 1 May 1994
PDF: 8 pages
Proc. SPIE 2168, Medical Imaging 1994: Physiology and Function from Multidimensional Images, (1 May 1994); doi: 10.1117/12.174414
Show Author Affiliations
Jacqueline Palmari, Univ. Aix-Marseille III (France)
Jean Yves Andre, Univ. Aix-Marseille II (France)
Pierre-Marie Martin, Univ. Aix-Marseille II (France)
Christophe Dussert, Univ. Aix-Marseille II (France)

Published in SPIE Proceedings Vol. 2168:
Medical Imaging 1994: Physiology and Function from Multidimensional Images
Eric A. Hoffman; Raj S. Acharya, Editor(s)

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