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Proceedings Paper

Near-field fiber optic chemical sensors and biological applications
Author(s): Weihong Tan; Zhong-You Shi; Bjorn A. Thorsrud; C. Harris; Raoul Kopelman
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Paper Abstract

Near-field optics has been applied in the nanofabrication of subwavelength optical fiber chemical and biological sensors and their operation in chemical and biological analysis. A thousandfold miniaturization of immobilized optical fiber sensors has been achieved by a near- field photo-nanofabrication technique, which is based on nanofabricated optical fiber tips and near-field photopolymerization. This technique has been further developed by multistep near- field nanofabrication and multidye probe fabrication. Multistep nanofabrication can further miniaturize optical fiber sensors, while multidye fabrication results in multifunctional optic and excitonic probes with extremely small size. These probes emit multiwavelength photons or produce excitons of different energy levels, and may have multiple chemical or biological sensitivities. The nondestructive submicrometer sensor has demonstrated its ability to carry out static and dynamic determinations of pH in intact rat conceptuses of varying gestational ages. The ability of the sensors to measure pH changes, in real time, in the intact rat conceptus, demonstrates their potential applications for dynamic analysis in multicellular organisms and single cells. The near-field interaction of photons with matter is discussed.

Paper Details

Date Published: 10 March 1994
PDF: 10 pages
Proc. SPIE 2068, Chemical, Biochemical, and Environmental Fiber Sensors V, (10 March 1994); doi: 10.1117/12.170651
Show Author Affiliations
Weihong Tan, Univ. of Michigan (United States)
Zhong-You Shi, Univ. of Michigan (United States)
Bjorn A. Thorsrud, Univ. of Michigan (United States)
C. Harris, Univ. of Michigan (United States)
Raoul Kopelman, Univ. of Michigan (United States)


Published in SPIE Proceedings Vol. 2068:
Chemical, Biochemical, and Environmental Fiber Sensors V
Robert A. Lieberman, Editor(s)

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