We investigated the ability of fluorescence spectroscopy, and photosensitizers to differentiate normal, hyperplastic and atherosclerotic arterial wall lesions in vivo. Hyperplastic lesions were induced in the abdominal aorta (AB) of 24 rabbits by balloon injury (BI). Atherosclerotic arterial wall lesions were induced by BI and diet. Fluorescence signals from thoracic n equals 16 and AB n equals 15 sites were analyzed by computer. A ratio was used as an index of drug presence. Use of PPS or BPD and LIFS may be a feasible, in vivo method for the differentiation between normal, hyperplastic and atherosclerotic arterial wall lesions.

Date Published: 15 February 1994
PDF: 9 pages
Proc. SPIE 2086, Medical Applications of Lasers, (15 February 1994); doi: 10.1117/12.169112

Published in SPIE Proceedings Vol. 2086:
Medical Applications of Lasers
Kazuhiko Atsumi M.D.; Cornelius Borst M.D.; Frank W. Cross M.D.; Herbert J. Geschwind M.D.; Dieter Jocham; Jan Kvasnicka; Hans H. Scherer M.D.; Mario A. Trelles; Eberhard Unsoeld, Editor(s)