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Proceedings Paper

Synthesis and biological evaluation of a series of new germanium phthalocyanines incorporated into liposomes--part I: chemistry
Author(s): Hans-Georg Capraro; Klaus Schieweck; Rolf Hilfiker; Martin Ochsner; Ute Isele; Peter van Hoogevest; R. Naef; M. E. Baumann
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Paper Abstract

Germanium-dihydroxy-phthalocyanine GePc(OH2) was synthesized and used as starting material for several new, axially disubstituted derivatives of the general formula GePc[OSi(R2)R']2. The preparation of the monosubstituted silanol side chains HOSi(R)2R' was performed either by Mitsunobu reaction starting from diphenylsilandiol Si(Ph)2(OH)2 followed by direct coupling of the side-chain with GePc(OH)2, or by synthesis from a dichlorosilyl derivative. The new compounds were fully characterized and the chemical and main photophysical properties determined. The absorption maxima of these compounds lie in the range of 675 nm. They were found to possess a high quantum efficiency of singlet-oxygen production and fluorescence. The compounds were incorporated into small, unilamellar liposomes following a technology developed by Ciba-Geigy. The dye-to-lipid ratio was 1:100. The liposomal suspensions were freeze-dried for storage. The new compounds were evaluated for their pharmacokinetic and phototherapeutic properties.

Paper Details

Date Published: 1 March 1994
PDF: 7 pages
Proc. SPIE 2078, Photodynamic Therapy of Cancer, (1 March 1994); doi: 10.1117/12.168716
Show Author Affiliations
Hans-Georg Capraro, CIBA-GEIGY Ltd. (Switzerland)
Klaus Schieweck, CIBA-GEIGY Ltd. (Switzerland)
Rolf Hilfiker, CIBA-GEIGY Ltd. (Switzerland)
Martin Ochsner, CIBA-GEIGY Ltd. (Switzerland)
Ute Isele, CIBA-GEIGY Ltd. (Switzerland)
Peter van Hoogevest, CIBA-GEIGY Ltd. (Switzerland)
R. Naef, CIBA-GEIGY Ltd. (Switzerland)
M. E. Baumann, CIBA-GEIGY Ltd. (Switzerland)

Published in SPIE Proceedings Vol. 2078:
Photodynamic Therapy of Cancer
Giulio Jori; Johan Moan; Willem M. Star, Editor(s)

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