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Proceedings Paper

Light dosage in whole bladder wall photodynamic therapy at 532 and 630 nm
Author(s): Hugo J. van Staveren; Joost W.H. Ramaekers; Johannes P. A. Marijnissen; Johan F. Beek; Marleen Keijzer; Willem M. Star
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Paper Abstract

The optical absorption, scattering and anisotropy coefficient of piglet and diseased human bladder tissue were determined in vitro in the wavelength range of 500 - 650 nm. Monte Carlo simulations for whole bladder wall (WBW) photodynamic therapy (PDT) have been performed using the optical parameters determined in vitro. The calculated light dose rate values are in agreement with those measured in clinical WBW-PDT, previously performed at 630 nm. The light dose rate at the bladder wall can differ by a factor of 4, due to variations in optical properties of the tissue. This demonstrates the necessity of in situ light dosimetry during clinical WBW-PDT. WBW-PDT with red light (630 nm) will be technically more advantageous than with green light (532 nm), because of a higher integrating sphere effect.

Paper Details

Date Published: 1 March 1994
PDF: 8 pages
Proc. SPIE 2078, Photodynamic Therapy of Cancer, (1 March 1994); doi: 10.1117/12.168715
Show Author Affiliations
Hugo J. van Staveren, Dr. Daniel den Hoed Cancer Ctr. (Netherlands)
Joost W.H. Ramaekers, Dr. Daniel den Hoed Cancer Ctr. (Netherlands)
Johannes P. A. Marijnissen, Dr. Daniel den Hoed Cancer Ctr. (Netherlands)
Johan F. Beek, Academic Medical Ctr. (Netherlands)
Marleen Keijzer, Delft Univ. of Technology (Netherlands)
Willem M. Star, Dr. Daniel den Hoed Cancer Ctr. (Netherlands)

Published in SPIE Proceedings Vol. 2078:
Photodynamic Therapy of Cancer
Giulio Jori; Johan Moan; Willem M. Star, Editor(s)

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