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Proceedings Paper

Photodynamic laser therapy with antibody-coupled phthalocyanine
Author(s): Birgit C. Schultes; Stefan B. Spaniol; Stephan Schmidt; Wolfgang Ertmer; Hans-Juergen Biersack; Dieter Krebs
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Paper Abstract

We developed a new water-soluble phthalocyanine, activated for coupling to antibodies by N- hydroxysulfosuccinimide. The efficiency of anti-CA125-phthalocyanine conjugates was compared to free phthalocyanine in a human ovarian carcinoma model in tissue culture. In both cases a dose dependent cell killing was observed after irradiation with a Titanium sapphire laser at 675 nm and 50 J/cm2, but incubation with antibody-coupled phthalocyanine resulted in 90% cell mortality with a 60-130-fold lower dye application.

Paper Details

Date Published: 1 March 1994
PDF: 10 pages
Proc. SPIE 2078, Photodynamic Therapy of Cancer, (1 March 1994); doi: 10.1117/12.168709
Show Author Affiliations
Birgit C. Schultes, Univ. Bonn (Germany)
Stefan B. Spaniol, Univ. Bonn (Germany)
Stephan Schmidt, Univ. Bonn (Germany)
Wolfgang Ertmer, Univ. Bonn (Germany)
Hans-Juergen Biersack, Univ. Bonn (Germany)
Dieter Krebs, Univ. Bonn (Germany)

Published in SPIE Proceedings Vol. 2078:
Photodynamic Therapy of Cancer
Giulio Jori; Johan Moan; Willem M. Star, Editor(s)

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