Proceedings Paper
Photodynamic laser therapy with antibody-coupled phthalocyanine| Format | Member Price | Non-Member Price |
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Paper Abstract
We developed a new water-soluble phthalocyanine, activated for coupling to antibodies by N- hydroxysulfosuccinimide. The efficiency of anti-CA125-phthalocyanine conjugates was compared to free phthalocyanine in a human ovarian carcinoma model in tissue culture. In both cases a dose dependent cell killing was observed after irradiation with a Titanium sapphire laser at 675 nm and 50 J/cm2, but incubation with antibody-coupled phthalocyanine resulted in 90% cell mortality with a 60-130-fold lower dye application.
Paper Details
Date Published: 1 March 1994
PDF: 10 pages
Proc. SPIE 2078, Photodynamic Therapy of Cancer, (1 March 1994); doi: 10.1117/12.168709
Published in SPIE Proceedings Vol. 2078:
Photodynamic Therapy of Cancer
Giulio Jori; Johan Moan; Willem M. Star, Editor(s)
PDF: 10 pages
Proc. SPIE 2078, Photodynamic Therapy of Cancer, (1 March 1994); doi: 10.1117/12.168709
Show Author Affiliations
Birgit C. Schultes, Univ. Bonn (Germany)
Stefan B. Spaniol, Univ. Bonn (Germany)
Stephan Schmidt, Univ. Bonn (Germany)
Stefan B. Spaniol, Univ. Bonn (Germany)
Stephan Schmidt, Univ. Bonn (Germany)
Wolfgang Ertmer, Univ. Bonn (Germany)
Hans-Juergen Biersack, Univ. Bonn (Germany)
Dieter Krebs, Univ. Bonn (Germany)
Hans-Juergen Biersack, Univ. Bonn (Germany)
Dieter Krebs, Univ. Bonn (Germany)
Published in SPIE Proceedings Vol. 2078:
Photodynamic Therapy of Cancer
Giulio Jori; Johan Moan; Willem M. Star, Editor(s)
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