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Proceedings Paper

Treatment of rat Walker-256 carcinosarcoma with photodynamic therapy and endotoxin irradiated with high-energy electrons
Author(s): Vasile F. Dima; Virgil V. Vasiliu; Dezideriu Laky; Mircea D. Ionescu; Stefan V. Dima
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Paper Abstract

Experiments were performed on five batches of Wistar inbred rats with Walker-256 carcinosarcoma receiving sole treatment photodynamic therapy (PDT), irradiated endotoxin (R-LPS), native-endotoxin (N-LPS), or associated therapy (PDT + R-LPS) and the control batch (saline) consisted of animals with untreated Walker-256 tumors. The results were as follows: the sole treatment (PDT, R-LPS, N-LPS) gave survival rates between 56.3 and 60.7% and cure rates ranging from 32.1 to 37.5%. The `combined' therapy in multiple doses increased significantly (88.6%) the survival rate of tumor bearing rats as well as the highest incidence of complete tumor regression (71.4%). This work demonstrates that `combined' photodynamic and immunotherapy with irradiated endotoxin stimulates cell-mediated antitumoral activity and induces changes in the tumoral incidence in Walker-256 carcinosarcoma in the rat model.

Paper Details

Date Published: 1 March 1994
PDF: 11 pages
Proc. SPIE 2078, Photodynamic Therapy of Cancer, (1 March 1994); doi: 10.1117/12.168706
Show Author Affiliations
Vasile F. Dima, Cantacuzino Institute (Romania)
Virgil V. Vasiliu, Institute of Atomic Physics (Romania)
Dezideriu Laky, Victor Babes Institute (Romania)
Mircea D. Ionescu, Cantacuzino Institute (Romania)
Stefan V. Dima, Cantacuzino Institute (Romania)

Published in SPIE Proceedings Vol. 2078:
Photodynamic Therapy of Cancer
Giulio Jori; Johan Moan; Willem M. Star, Editor(s)

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