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Proceedings Paper

Highly substituted phthalocyanine derivatives as potential photosensitizers for photodynamic therapy of tumors
Author(s): Michael J. Cook; Clara Fabris; Cristina Ometto; Denise A. Mayes; Giulio Jori; Jim McMurdo; Carla Milanesi; David A. Russell
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Paper Abstract

An octakis-decyl-substituted Zn(II)-phthalocyanine (ZnODPc) was prepared by chemical synthesis and was shown to possess favorable photophysical properties to act as a photodynamic agent. Intravenous injection of ZnODPc incorporated into Cremophor emulsions (1.2 or 2.4 mg/kg) to Balb/c mice bearing a MS-2 fibrosarcoma resulted in an efficient and selective accumulation of the phthalocyanine in the tumor. Illumination of the ZnODPc-loaded neoplastic lesion at 24 h after injection caused tumor regression as a result of both intracellular and intravascular damage.

Paper Details

Date Published: 1 March 1994
PDF: 8 pages
Proc. SPIE 2078, Photodynamic Therapy of Cancer, (1 March 1994); doi: 10.1117/12.168705
Show Author Affiliations
Michael J. Cook, Univ. of East Anglia (United Kingdom)
Clara Fabris, Univ. of Padova (Italy)
Cristina Ometto, Univ. of Padova (Italy)
Denise A. Mayes, Univ. of East Anglia (United Kingdom)
Giulio Jori, Univ. of Padova (Italy)
Jim McMurdo, Univ. of East Anglia (United Kingdom)
Carla Milanesi, Univ. of Padova (Italy)
David A. Russell, Univ. of East Anglia (United Kingdom)

Published in SPIE Proceedings Vol. 2078:
Photodynamic Therapy of Cancer
Giulio Jori; Johan Moan; Willem M. Star, Editor(s)

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