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Proceedings Paper

Efficiency of photodynamic therapy under pulsed laser radiation: model investigations
Author(s): Valentinas Mickunaitis; Ricardas Rotomskis
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Paper Abstract

Photochemical reactions under the action of powerful ultrashort laser pulses occur with excitation of sensitizers to high lying singlet and triplet states can be quite different from those occurring from S1 and T1 and in some cases have greater photochemical and photobiological efficiency in vivo and in vitro. In our paper we are modelling the primary photoprocesses in hematoporphyrin molecules under the excitation by cw and pulsed light. On the basis of the proposed theoretical model the pulse duration and intensity region, where photobleaching of ground state absorption and absorption from exited singlet and triplet states have influence on the type II photodynamic processes, was estimated. The results show that Hp ground state bleaching and the efficiency of photodynamic therapy is reduced when the pulse energy is over the value 10 mJ/cm2. The dependence of the efficiency of the photochemistry from triplet state on laser pulse intensity and duration was studied. The published results of some PDT experiments in comparison with efficiency curve based on our model are presented.

Paper Details

Date Published: 1 March 1994
PDF: 5 pages
Proc. SPIE 2078, Photodynamic Therapy of Cancer, (1 March 1994); doi: 10.1117/12.168696
Show Author Affiliations
Valentinas Mickunaitis, Vilnius Univ. (Lithuania)
Ricardas Rotomskis, Vilnius Univ. (Lithuania)

Published in SPIE Proceedings Vol. 2078:
Photodynamic Therapy of Cancer
Giulio Jori; Johan Moan; Willem M. Star, Editor(s)

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