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Proceedings Paper

Photophysics of sulphonated aluminum phthalocyanines in reversed micelles
Author(s): Suman Dhami; Juan J. Cosa; Steven M. Bishop; Mary S. C. Simpson; David Phillips
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Paper Abstract

The photophysics of sulphonated aluminum phthalocyanines, AlPcSn (n equals 0, 1, 2, 3 or 4), potential second-generation phototherapeutic agents for tumors, in cationic reversed micelles of benzyl ammonium hexadecyl chloride (BHDC) and anionic reversed micelles of sodium di(2-ethylhexyl) sulphosuccinate (AOT) have been investigated. Absorption spectroscopy, as well as steady state and time-resolved fluorescence emission studies, indicate that in BHDC the di- and tri-sulphonated derivatives are essentially monomeric whereas in AOT only the di-sulphonated phthalocyanine was found to be monomeric. The distribution of AlPcSn in the reversed micelles, which appears to be strongly influenced by the extent of sulphonation and the environment of the reversed micelle, is discussed. It is anticipated that extrapolation can then be made to heterogeneous systems such as are found in biomembranes.

Paper Details

Date Published: 1 March 1994
PDF: 8 pages
Proc. SPIE 2078, Photodynamic Therapy of Cancer, (1 March 1994); doi: 10.1117/12.168691
Show Author Affiliations
Suman Dhami, Imperial College of Science, Technology and Medicine (United Kingdom)
Juan J. Cosa, Imperial College of Science, Technology and Medicine (United Kingdom)
Steven M. Bishop, Imperial College of Science, Technology and Medicine (United Kingdom)
Mary S. C. Simpson, Imperial College of Science, Technology and Medicine (United Kingdom)
David Phillips, Imperial College of Science, Technology and Medicine (United Kingdom)


Published in SPIE Proceedings Vol. 2078:
Photodynamic Therapy of Cancer
Giulio Jori; Johan Moan; Willem M. Star, Editor(s)

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