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Proceedings Paper

Time-resolved fluorescence spectroscopy of tetrasulfonated aluminum phthalocyanine in solution and cells
Author(s): L. V. Zhorina; Andrey Yuri Chikishev; Maria G. Galpern; Marina Yu. Poroshina; Elena B. Chernyaeva
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Paper Abstract

Tetrasulphonated aluminum phthalocyanine (AlPcS4) is one of the extensively studied second generation sensitizers for photodynamic therapy of cancer. We've applied picosecond fluorescence spectroscopy to study the fluorescence decay lifetimes of AlPcS4 in phosphate buffer at different pH values and in monolayers of cultured cells incubated in photosensitizer solution. The decay time for the cells in the buffer is closer to the one obtained for acidic aqueous solution indicating that at least part of the phthalocyanine could be found in the acidic microenvironment (lysosomes, etc.).

Paper Details

Date Published: 1 March 1994
PDF: 4 pages
Proc. SPIE 2078, Photodynamic Therapy of Cancer, (1 March 1994); doi: 10.1117/12.168690
Show Author Affiliations
L. V. Zhorina, Moscow State Univ. (Russia)
Andrey Yuri Chikishev, Moscow State Univ. (Russia)
Maria G. Galpern, Institute of Organic Intermediates and Dyes (Russia)
Marina Yu. Poroshina, Moscow State Univ. (Russia)
Elena B. Chernyaeva, Moscow State Univ. (Russia)

Published in SPIE Proceedings Vol. 2078:
Photodynamic Therapy of Cancer
Giulio Jori; Johan Moan; Willem M. Star, Editor(s)

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