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Proceedings Paper

Fluorescence resonance energy transfer measurements as a tool to detect fusion and drug exchange in liposomal suspensions
Author(s): Rolf Hilfinker; Annette Willi; Ute Isele; Peter van Hoogevest
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Paper Abstract

Zinc-(II)-phthalocyanine (ZnPc) is a drug that can potentially be used in photodynamic therapy. A promising formulation approach for the strongly hydrophobic ZnPc is to embed the molecule in liposomes. CGP 55847 is such a liposomal ZnPc formulation. From our data, we could conclude that approximately one quarter of the drug molecules were only loosely bound to the liposomes and exchanged between them with a relaxation time of about 15 min. Energy transfer measurements before and after the lyophilization process revealed that the liposomes were stable when suspended in a 10% lactose solution, i.e. no fusion of liposomes took place. In aqueous solution, however, lyophilization induced fusion of liposomes to a small extent with a concomitant increase in size.

Paper Details

Date Published: 1 March 1994
PDF: 4 pages
Proc. SPIE 2078, Photodynamic Therapy of Cancer, (1 March 1994); doi: 10.1117/12.168689
Show Author Affiliations
Rolf Hilfinker, CIBA-GEIGY Ltd. (Switzerland)
Annette Willi, CIBA-GEIGY Ltd. (Switzerland)
Ute Isele, CIBA-GEIGY Ltd. (Switzerland)
Peter van Hoogevest, CIBA-GEIGY Ltd. (Switzerland)

Published in SPIE Proceedings Vol. 2078:
Photodynamic Therapy of Cancer
Giulio Jori; Johan Moan; Willem M. Star, Editor(s)

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