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Proceedings Paper

Synthesis of axially disubstituted octakis-alkoxy-germanium(IV) phthalocyanines
Author(s): M. E. Baumann; Hans-Georg Capraro; Rolf Hilfinker; Martin Ochsner
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Paper Abstract

A series of new octakis-substituted Germanium-phthalocyanines for use in photodynamic therapy of tumors has been synthesized. Starting from 1,4-dialkoxy-2,3-dicyano-benzene the metal-free octakis-alkoxy-phthalocyanine 13 was prepared. The metallation to the corresponding octakis-alkoxy-GeCl2-phthalocyanine 15 was done with a GeCl4-DMF complex. Alkaline hydrolysis gave quantitatively the octakis-alkoxy-Ge(OH)2- phthalocyanine 16. By substitution of the hydroxy groups with alcohols, thiols and silanols the axially disubstituted phthalocyanines were obtained. The most important photophysical properties for PDT (Q-bands, singlet oxygen quantum yields and (Phi) f) are reported.

Paper Details

Date Published: 1 March 1994
PDF: 7 pages
Proc. SPIE 2078, Photodynamic Therapy of Cancer, (1 March 1994); doi: 10.1117/12.168688
Show Author Affiliations
M. E. Baumann, CIBA-GEIGY Ltd. (Switzerland)
Hans-Georg Capraro, CIBA-GEIGY Ltd. (Switzerland)
Rolf Hilfinker, CIBA-GEIGY Ltd. (Switzerland)
Martin Ochsner, CIBA-GEIGY Ltd. (Switzerland)

Published in SPIE Proceedings Vol. 2078:
Photodynamic Therapy of Cancer
Giulio Jori; Johan Moan; Willem M. Star, Editor(s)

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