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Proceedings Paper

Pharmakokinetics of 132-hydroxy-bacteriopheophorbide: a methyl ester studied by fluorescence spectroscopy on Lewis lung carcinoma bearing mice
Author(s): Beate Roeder; Cathrin Dressler; B. Fuchs; Roland Hagemann; Hans-Peter Berlien; Christian Nowak; Joerg G. Moser
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Paper Abstract

The pharmacokinetics of 132-hydroxy-bacteriopheophorbide a methyl ester (OH-BPME) was studied on Lewis lung carcinoma bearing mice by fluorescence spectroscopy. The sensitizer distribution in different organs and in the tumor was investigated in dependence on the incubation time. A very fast cleaning of the blood and the skin was observed. The results of our investigations suggest that PDT using OH-BPME could be effective at sensitizer incubation times of about 12 h.

Paper Details

Date Published: 1 March 1994
PDF: 11 pages
Proc. SPIE 2078, Photodynamic Therapy of Cancer, (1 March 1994); doi: 10.1117/12.168685
Show Author Affiliations
Beate Roeder, Humboldt-Univ. Berlin (Germany)
Cathrin Dressler, Free Univ. Berlin (Germany)
B. Fuchs, Laser Medicine Ctr. Berlin (Germany)
Roland Hagemann, Laser Medicine Ctr. Berlin (Germany)
Hans-Peter Berlien, Free Univ. Berlin and Laser Medicine Ctr. Berlin (Germany)
Christian Nowak, Max-Delbrueck Institute Berlin (Germany)
Joerg G. Moser, Heinrich-Heine Univ. (Germany)

Published in SPIE Proceedings Vol. 2078:
Photodynamic Therapy of Cancer
Giulio Jori; Johan Moan; Willem M. Star, Editor(s)

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