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Proceedings Paper

Distribution of photosensitizers between tumor cells and tumor infiltrating host cells
Author(s): Mladen Korbelik; Gorazd Krosl
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Paper Abstract

Photofrin levels in different cellular populations constituting a murine FsaR fibrosarcoma were measured by flow cytometry. Both myeloid and lymphoid populations associated with the tumor were found to accumulate more photosensitizer on a per cell basis, on average, than the malignant cells. Macrophages, identified by the F4/80 antigen, exceeded other myeloid cells in Photofrin accumulation. It is shown that one of the factors involved is the variability in the photosensitizer content in cells located at different distances from the nearest blood vessel. This was investigated by a flow cytometry technique with the fluorescent stain Hoechst 33342, used to distinguish cells depending on their proximity to the tumor vasculature.

Paper Details

Date Published: 1 March 1994
PDF: 8 pages
Proc. SPIE 2078, Photodynamic Therapy of Cancer, (1 March 1994); doi: 10.1117/12.168679
Show Author Affiliations
Mladen Korbelik, British Columbia Cancer Research Ctr. (Canada)
Gorazd Krosl, British Columbia Cancer Research Ctr. (Canada)

Published in SPIE Proceedings Vol. 2078:
Photodynamic Therapy of Cancer
Giulio Jori; Johan Moan; Willem M. Star, Editor(s)

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