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Preliminary clinical studies of PDT with meso-tetrahydroxyphenyl chlorin (m-THPC) as a photosensitizing agent for the treatment of early pharyngeal, esophageal, and bronchial carcinomas
Author(s): Jean-Francois Savary; Philippe Monnier; Georges A. Wagnieres; Daniel Braichotte; Charlotte Fontolliet; Hubert van den Bergh
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Paper Abstract

A new photosensitizer (PS), meso-tetrahydroxyphenyl-chlorin(m-THPC), has been clinically evaluated for photodynamic therapy (PDT) of early squamous cell carcinomas located in the upper aerodigestive tract, the oesophagus and the tracheobronchial tree. The injected doses ranged between 0.1 - 0.3 mg/kg m-THPC and the wavelength of the excitation light was either at 514 nm or 652 nm. The evaluation of the m-THPC induced phototoxicity was carried out on healthy mucosae of the bronchi, the oral cavity and the skin, using various `frontal' light distributors. Skin photosensitization tests were performed with a filtered Xenon white light source which simulates the solar emission spectrum at noon on a clear summer day at sea level at our latitude. At the present time, we are still searching for conditions where effective PDT with m-THPC of early carcinomas of the upper aerodigestive tract, the oesophagus and the tracheobronchial tree would show a real selectivity, i.e., destruction of the neoplastic tissue without necrosis of the surrounding normal tissue.

Paper Details

Date Published: 1 March 1994
PDF: 11 pages
Proc. SPIE 2078, Photodynamic Therapy of Cancer, (1 March 1994); doi: 10.1117/12.168671
Show Author Affiliations
Jean-Francois Savary, CHUV Hospital (Switzerland)
Philippe Monnier, CHUV Hospital (Switzerland)
Georges A. Wagnieres, Ecole Polytechnique Federale de Lausanne (Switzerland)
Daniel Braichotte, Ecole Polytechnique Federale de Lausanne (Switzerland)
Charlotte Fontolliet, Univ. of Lausanne (Switzerland)
Hubert van den Bergh, Ecole Polytechnique Federale de Lausanne (Switzerland)

Published in SPIE Proceedings Vol. 2078:
Photodynamic Therapy of Cancer
Giulio Jori; Johan Moan; Willem M. Star, Editor(s)

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