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Proceedings Paper

Antimicrobial and antiviral activity of porphyrin photosensitization
Author(s): Zvi Malik; Hava Ladan; Yeshayahu Nitzan; Zehava Smetana
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Paper Abstract

In order to photosensitize Gram (-) bacteria such as Pseudomonas aeuruginosa and Escherichia coli, we introduced the small peptide polymyxin-B nona-peptide (PBNP) which stimulated the translocation of porphyrin through the outer membrane of these bacteria and makes PDT possible. Gram negative cell killing by the use of PBNP and DP broadens the antibacterial spectrum of photodynamic inactivation and opens new horizons for this modality as a wide spectrum drug when antibiotic resistance is the main concern. Plasmidial and chromosomal DNA damage in S. aureus and E. coli cells was mediated by DP photosensitization. The major observation was the disappearance of the plasmid supercoiled fraction. The chromosomal DNA was also affected and its degradation products were detected after treatment.

Paper Details

Date Published: 1 March 1994
PDF: 8 pages
Proc. SPIE 2078, Photodynamic Therapy of Cancer, (1 March 1994); doi: 10.1117/12.168668
Show Author Affiliations
Zvi Malik, Bar-Ilan Univ. (Israel)
Hava Ladan, Bar-Ilan Univ. (Israel)
Yeshayahu Nitzan, Bar-Ilan Univ. (Israel)
Zehava Smetana, Bar-Ilan Univ. (Israel)

Published in SPIE Proceedings Vol. 2078:
Photodynamic Therapy of Cancer
Giulio Jori; Johan Moan; Willem M. Star, Editor(s)

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