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Proceedings Paper

Effect of sulfonation on the photosensitizing efficiency of aluminum phthalocyanine and meso-tetraphenylporphine in photodynamic therapy of cancer
Author(s): Qian Peng; Li Wei Ma; Kristian Berg; Johan Moan
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Paper Abstract

The effect of sulfonations on the PDT efficiency of aluminum phthalocyanines and meso- tetraphenylporphines was studied in the CaD2 mouse mammary carcinoma. The PDT efficiencies were found to decrease in the following order: AlPCS2 > AlPCS4 > Photofrin > TPPS2a > AlPCS1 > TPPS4 > TPPS2o > TPPS1. Apparently, the degree of sulfonations of both families of dyes strongly affects the photobiological properties. It was found to be of great importance whether the sulfonate groups were located adjacently or opposite positions on the molecules.

Paper Details

Date Published: 1 March 1994
PDF: 10 pages
Proc. SPIE 2078, Photodynamic Therapy of Cancer, (1 March 1994); doi: 10.1117/12.168662
Show Author Affiliations
Qian Peng, Institute for Cancer Research (Norway)
Li Wei Ma, Institute for Cancer Research (Norway)
Kristian Berg, Institute for Cancer Research (Norway)
Johan Moan, Institute for Cancer Research (Norway)

Published in SPIE Proceedings Vol. 2078:
Photodynamic Therapy of Cancer
Giulio Jori; Johan Moan; Willem M. Star, Editor(s)

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