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Proceedings Paper

In vitro photosensitizing activity of benzoporphyrin derivative monoacid ring A using pulsed and continuous-wave irradiation
Author(s): Heyke Cacile Diddens; Robert Gillies; Tayyaba Hasan
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Paper Abstract

Benzoporphyrin derivative monoacid ring A (BPD-MA) is a potent new photosensitizer with a significant extinction coefficient at 690 nm. In this study, the photosensitizing efficacy of BPD-MA irradiated at 694 nm with continuous wave (cw) radiation from an argon ion laser pumped dye laser and high intensity pulsed radiation from a ruby laser was compared. Human bladder carcinoma cells in vitro were treated with 0.14 (mu) M BPD-MA for 3 h, washed, then irradiated with either cw or pulsed irradiation. A cumulative cw radiant exposure of 1 or 3 J/cm2 led to cellular survival rates of 38% and 6% respectively compared to untreated controls. Essentially no phototoxicity was observed at the high intensity pulsed powers used in this study.

Paper Details

Date Published: 1 March 1994
PDF: 7 pages
Proc. SPIE 2078, Photodynamic Therapy of Cancer, (1 March 1994); doi: 10.1117/12.168655
Show Author Affiliations
Heyke Cacile Diddens, Medizinisches Laserzentrum (Germany)
Robert Gillies, Wellman Labs. of Photomedicine (United States)
Tayyaba Hasan, Wellman Labs. of Photomedicine (United States)

Published in SPIE Proceedings Vol. 2078:
Photodynamic Therapy of Cancer
Giulio Jori; Johan Moan; Willem M. Star, Editor(s)

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