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Proceedings Paper

Photodynamic therapy photosensitizers derived from chlorophyll a
Author(s): Raymond Bonnett; Robin Benzie; Michael F. Grahn; A. Salgado; Maria Asuncion Valles
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Paper Abstract

A series of hydroxychlorins and another of (omega) -carboxyalkyloxy derivatives have been prepared from chlorophyll (alpha) , and their potential photosensitizing ability for the photodynamic therapy of cancer tested in vitro by the MTT assay. The results show that the monohydroxychlorin VI, because of its high photoactivity and its low dark toxicity, is the most promising compound of these series.

Paper Details

Date Published: 1 March 1994
PDF: 8 pages
Proc. SPIE 2078, Photodynamic Therapy of Cancer, (1 March 1994); doi: 10.1117/12.168650
Show Author Affiliations
Raymond Bonnett, Queen Mary and Westfield College (United Kingdom)
Robin Benzie, Royal London Hospital Medical College (United Kingdom)
Michael F. Grahn, Royal London Hospital Medical College (United Kingdom)
A. Salgado, Queen Mary and Westfield College (United Kingdom)
Univ. de Barcelona (Spain)
Maria Asuncion Valles, Univ. de Barcelona (Spain)

Published in SPIE Proceedings Vol. 2078:
Photodynamic Therapy of Cancer
Giulio Jori; Johan Moan; Willem M. Star, Editor(s)

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