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Proceedings Paper

Potent photosensitizers for PDT of cancer: application of confocal laser scanning microscopy for fluorescence detection of photosensitizing fluorophores in neoplastic cells and tissues
Author(s): Qian Peng; Havard E. Danielsen; Johan Moan
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Paper Abstract

By using confocal laser scanning microscopy (CLSM), intracellular and intratumoral fluorescence localization of several promising photosensitizing fluorophores, such as the derivatives of sulfonated aluminum phthalocyanines (AlPCSn, n equals 1-4), meso- tetra(hydroxyphenyl)porphine (m-THPP) and its chlorin (m-THPC) was studied in several cancer cell lines in vitro and in tumor models in vivo. The correlation of the subcellular and intratumoral localization patterns of the potent photosensitizers with the targets of photodynamic action is discussed. Also, the advantages of using CLSM for studying the fluorescence properties of the photosensitizing fluorochromes in a biological system is emphasized.

Paper Details

Date Published: 1 February 1994
PDF: 12 pages
Proc. SPIE 2083, Microscopy, Holography, and Interferometry in Biomedicine, (1 February 1994); doi: 10.1117/12.167422
Show Author Affiliations
Qian Peng, Institute for Cancer Research (Norway)
Havard E. Danielsen, Institute for Cancer Research (Norway)
Johan Moan, Institute for Cancer Research (Norway)

Published in SPIE Proceedings Vol. 2083:
Microscopy, Holography, and Interferometry in Biomedicine
Adolf Friedrich Fercher; Aaron Lewis; Halina Podbielska M.D.; Herbert Schneckenburger; Tony Wilson, Editor(s)

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