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Proceedings Paper

Computer tomography assisted laser intervention
Author(s): Adam R. Mester; Ernoe Mako
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Paper Abstract

Radiological procedures to destroy deep neoplastic laesions of internal organs - without surgical exploration is a highly instnimentation dependent technique, reducing the risk for patients and the costs of hospitalisation. Nonturnor therapeutic radiology can be used for chernolysis: syrnpathectomy, discectorny, but there is a danger of complications because of uncontrolable fluid distribu— tion, wich can produce unexpected necrosis. Laser, guided by radiologiacal imaging methods, gives the possibility of precise intervention /nucleus pulposus denaturalisation or brain tumor fiber optic destruction, as introduced by Ascher/. Laser — intersti— tial — hypertherrnia is a new method /developed by Bown/ to increase the tumor destruction, and it promotes the effect of other anti— tumo r therapies, as radiotherapy, cytostatic therapy or photodynainic therapy. Photodynarnic therapy by systemic administration causes a skin photosensitivity for 30 — 40 days, and the hernatoporphyrin concentration in the tumor tissue is only 1 — 2 ,ug/g. Ideal application for deep tumor effective laser desstruction was developed by Gatenby: CT — guided fiberoptic direct injection of HpD prepared PDT. The direct HpD injection into the tumor reults 50 — 100 ,ug/g concentration of the photosensitiser in the tumor tissue, without systemic effects, as skin photosensitivity. That's, why the exposure can be repeated at weekly intervals. Under 2 cm size the results are excellent, but even larger masses, have had not respomided to conventional therapy showed significant improvement in size and in pain aswell. The procedure can be on outpatient basis

Paper Details

Date Published: 1 February 1994
PDF: 6 pages
Proc. SPIE 2084, Biomedical Optoelectronic Devices and Systems, (1 February 1994); doi: 10.1117/12.167322
Show Author Affiliations
Adam R. Mester, Semmelweiss Univ. of Medical Sciences (Hungary)
Ernoe Mako, Semmelweiss Univ. of Medical Sciences (Hungary)

Published in SPIE Proceedings Vol. 2084:
Biomedical Optoelectronic Devices and Systems
Nathan I. Croitoru; Riccardo Pratesi, Editor(s)

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