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Proceedings Paper

Raman spectrosopic characterization of human malignant tissues: implications for a percutaneous optical biopsy technique for in-situ tissue diagnosis
Author(s): Douglas C. B. Redd M.D.; Christopher J. Frank; Zhe Chuan Feng; Ted S. Gansler; Richard L. McCreery
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Paper Abstract

Recent advancements in the technique of Raman spectroscopy now make it possible to achieve rapid, minimally invasive and non-destructive characterization of tissues. In order to evaluate the efficacy of this technique for diagnosis, the Raman spectra of normal and neoplastic human tissues (e.g., breast, kidney, liver and colon) were obtained utilizing visible and near-IR excitation. Normal breast tissue and colon adenocarcinoma showed major Raman features due to the presence of carotenoids and lipids. In breast carcinoma, the features due to lipids were attenuated and as fibrosis (desmoplasia) increased, new spectral features attributable to collagen were observed. Samples of normal and neoplastic liver and kidney show unique spectral differences sufficient to permit tissue differentiation.

Paper Details

Date Published: 15 January 1994
PDF: 6 pages
Proc. SPIE 2081, Optical Biopsy, (15 January 1994); doi: 10.1117/12.166824
Show Author Affiliations
Douglas C. B. Redd M.D., Hospital of the Univ. of Pennsylvania (United States)
Christopher J. Frank, Ohio State Univ. (United States)
Zhe Chuan Feng, National Univ. of Singapore (Singapore)
Ted S. Gansler, Emory Univ. School of Medicine (United States)
Richard L. McCreery, Ohio State Univ. (United States)

Published in SPIE Proceedings Vol. 2081:
Optical Biopsy
Rinaldo Cubeddu; Sune Svanberg; Hubert van den Bergh, Editor(s)

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