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Proceedings Paper

Evaluation of film coating process with FTIR
Author(s): Astrid Arbin; Anders Ringberg; Martin Sandberg; Jan Oestelius
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Paper Abstract

Film coating of oral solid preparations is used for tastemasking and controlled release purposes. The evaluation of the film coating process, both during product development and for in-process control, is mostly done by in-vitro dissolution studies. These studies are however rather time consuming and do not give complete information about the film properties or the surface composition of the product, which is important both in terms of drug release rates and long term stability. In this work Fourier transform infrared spectroscopy with photoacoustic detection was used for characterization of polymer films directly on the finished drug preparation. The results obtained are compared with in-vitro dissolution and electron microscopy studies.

Paper Details

Date Published: 31 January 1994
PDF: 2 pages
Proc. SPIE 2089, 9th International Conference on Fourier Transform Spectroscopy, (31 January 1994); doi: 10.1117/12.166754
Show Author Affiliations
Astrid Arbin, Kabi Pharmacia Therapeutics (Sweden)
Anders Ringberg, Kabi Pharmacia Therapeutics (Sweden)
Martin Sandberg, Kabi Pharmacia Therapeutics (Sweden)
Jan Oestelius, Kabi Pharmacia Therapeutics (Sweden)

Published in SPIE Proceedings Vol. 2089:
9th International Conference on Fourier Transform Spectroscopy
John E. Bertie; Hal Wieser, Editor(s)

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