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Proceedings Paper

Quantification of tissue chromophore concentration via water-peak measurements in near-infrared spectroscopy
Author(s): Steven J. Matcher; Mark Cope; David T. Delpy
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Paper Abstract

We describe a simple method for measuring the differential pathlength of photons in a scattering medium utilizing the absorption features of water. The method allows quantification of chromophore concentration changes measured by near infrared spectroscopy without the need for time- or frequency-resolved measurements. We present the results of validation experiments performed on tissue phantoms and in-vivo comparisons between the differential path estimates yielded by water absorption and time-resolved measurements. We discus the accuracy of the differential path estimates provided by both the 975 nm and the 840 nm water features, finding that while the 840 nm feature is measured with lower accuracy for a given light flux, it is intrinsically a more accurate differential path estimator.

Paper Details

Date Published: 14 September 1993
PDF: 9 pages
Proc. SPIE 1888, Photon Migration and Imaging in Random Media and Tissues, (14 September 1993); doi: 10.1117/12.154639
Show Author Affiliations
Steven J. Matcher, Univ. College London (United Kingdom)
Mark Cope, Univ. College London (United Kingdom)
David T. Delpy, Univ. College London (United Kingdom)

Published in SPIE Proceedings Vol. 1888:
Photon Migration and Imaging in Random Media and Tissues
Britton Chance; Robert R. Alfano, Editor(s)

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