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Proceedings Paper

Automated method for relating regional pulmonary structure and function: integration of dynamic multislice CT and thin-slice high-resolution CT
Author(s): Jehangir K. Tajik; Steven D. Kugelmass; Eric A. Hoffman
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Paper Abstract

We have developed a method utilizing x-ray CT for relating pulmonary perfusion to global and regional anatomy, allowing for detailed study of structure to function relationships. A thick slice, high temporal resolution mode is used to follow a bolus contrast agent for blood flow evaluation and is fused with a high spatial resolution, thin slice mode to obtain structure- function detail. To aid analysis of blood flow, we have developed a software module, for our image analysis package (VIDA), to produce the combined structure-function image. Color coded images representing blood flow, mean transit time, regional tissue content, regional blood volume, regional air content, etc. are generated and imbedded in the high resolution volume image. A text file containing these values along with a voxel's 3-D coordinates is also generated. User input can be minimized to identifying the location of the pulmonary artery from which the input function to a blood flow model is derived. Any flow model utilizing one input and one output function can be easily added to a user selectable list. We present examples from our physiologic based research findings to demonstrate the strengths of combining dynamic CT and HRCT relative to other scanning modalities to uniquely characterize pulmonary normal and pathophysiology.

Paper Details

Date Published: 29 July 1993
PDF: 12 pages
Proc. SPIE 1905, Biomedical Image Processing and Biomedical Visualization, (29 July 1993); doi: 10.1117/12.148647
Show Author Affiliations
Jehangir K. Tajik, Univ. of Pennsylvania School of Medicine (United States)
Steven D. Kugelmass, Univ. of Pennsylvania School of Medicine (United States)
Eric A. Hoffman, Univ. of Pennsylvania School of Medicine (United States)

Published in SPIE Proceedings Vol. 1905:
Biomedical Image Processing and Biomedical Visualization
Raj S. Acharya; Dmitry B. Goldgof, Editor(s)

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