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Proceedings Paper

Free-electron laser irradiation of the cornea
Author(s): Denis M. O'Day M.D.; Richard F. Haglund Jr.; Regan Logan M.D.; Michael Borne
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Paper Abstract

The Free Electron laser was used to explore ablative and toxic effects of infrared irradiation of the cornea at wavelengths ranging from 2.5 - 4.0 micrometers including the peak absorptive wavelength for water of 2.94 micrometers . The macropulse length was 6 microsecond(s) . Effects were studied by visible light and scanning electron microscopies. Ablation was noted at a threshold fluence of 550 - 750 mJ(DOT)cm-2 and above at a wavelength of 2.94 micrometers . Ablation was accompanied by a distinct zone of tissue denaturation extending up to 12 micrometers into the adjacent tissue. Thermal denaturation appears to be a significant effect of infrared free-electron irradiation on the cornea and appears to be a consequence of the relatively long macropulse duration.

Paper Details

Date Published: 14 July 1993
PDF: 7 pages
Proc. SPIE 1854, Free-Electron Laser Spectroscopy in Biology, Medicine, and Materials Science, (14 July 1993);
Show Author Affiliations
Denis M. O'Day M.D., Vanderbilt Univ. (United States)
Richard F. Haglund Jr., Vanderbilt Univ. (United States)
Regan Logan M.D., Vanderbilt Univ. (United States)
Michael Borne, Vanderbilt Univ. (United States)

Published in SPIE Proceedings Vol. 1854:
Free-Electron Laser Spectroscopy in Biology, Medicine, and Materials Science
H. Alan Schwettman, Editor(s)

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