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Proceedings Paper

Study of erythrocyte-aggregation kinetics in shear flow in vitro by light-scattering technique
Author(s): Nikolai N. Firsov; Alexander V. Priezzhev; Olga M. Ryaboshapka
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Paper Abstract

The kinetics of aggregation and disaggregation of red blood cells in whole blood subjected to shear stress is different with normal and pathological blood. To measure this kinetics, we have applied a backscattering nephelometric technique, and quantitatively registered the alteration of the scattered intensity due to appearance or disappearance of different types of cell aggregates under controlled shear stresses. Fresh samples of normal and pathological blood from 25 patients suffering psoriatic arthritis were tested and showed differences in the RBCs (dis)aggregation kinetics. Relaxation times, index of hydrodynamic durability, and anisotropy of light scattering along and across to flow were discussed.

Paper Details

Date Published: 2 June 1993
PDF: 9 pages
Proc. SPIE 1981, Optical Methods of Biomedical Diagnostics and Therapy, (2 June 1993); doi: 10.1117/12.146467
Show Author Affiliations
Nikolai N. Firsov, Russian State Medical Univ. and Moscow State Univ. (Russia)
Alexander V. Priezzhev, Moscow State Univ. (Russia)
Olga M. Ryaboshapka, Moscow State Univ. (Russia)

Published in SPIE Proceedings Vol. 1981:
Optical Methods of Biomedical Diagnostics and Therapy
Valery V. Tuchin, Editor(s)

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