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Proceedings Paper

Antithrombotic and thrombolytic effects of antithrombin: comparison with either heparin or defibrase
Author(s): Takanobu Tomaru M.D.; Fumitaka Nakamura M.D.; Atsuko Miwa M.D.; Yoshiharu Fujimori M.D.; Yasumi Uchida M.D.
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Paper Abstract

Anti-thrombotic and thrombolytic effects of anti-thrombin agent (Argatroban;Arg 0.5 mg/kg) was evaluated by angioscopy and compared with heparin (250 U/kg). Occlusive thrombus was produced in canine iliac artery by balloon injury. At another side, balloon denudation was attempted at 20 minutes after the administration of the agent. One hour thrombus was control. Angioscopic percent luminal obstruction with thrombus reduced by Arg (from 69 to 32%, P < 0.0001), but not by heparin (from 53% to 59%). Both agents had antithrombotic effects and prevented thrombus formation. The activated partial thromboplastin time (APTT) prolonged to 190% with argatroban and 1253% with heparin (P < 0.0001). Thus, antithrombin agent has both preventive effect of thrombosis and thrombolytic effect without marked prolongation of the APTT.

Paper Details

Date Published: 28 May 1993
PDF: 4 pages
Proc. SPIE 1893, Optical Fibers in Medicine VIII, (28 May 1993); doi: 10.1117/12.146350
Show Author Affiliations
Takanobu Tomaru M.D., Univ. of Tokyo (Japan)
Fumitaka Nakamura M.D., Univ. of Tokyo (Japan)
Atsuko Miwa M.D., Univ. of Tokyo (Japan)
Yoshiharu Fujimori M.D., Univ. of Tokyo (Japan)
Yasumi Uchida M.D., Univ. of Tokyo (Japan)

Published in SPIE Proceedings Vol. 1893:
Optical Fibers in Medicine VIII
Abraham Katzir, Editor(s)

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