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Proceedings Paper

Spectroscopic studies of interactions between dyes and model molecules of Alzheimer's disease
Author(s): A. Elhaddaoui; A. Delacourte; S. Turrell
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Paper Abstract

Raman, FTIR, fluorescence, and UV-visible spectra are used to study interactions between amuloid-labelling dyes and poly-L-lysine and bovine insulin, two proteins which play the role of models of (beta) amyloid of Alzheimers disease. It is found that though the (beta) conformation of the peptide is not essential, it helps to encourage binding which appears to be stable and specific in nature, involving SO3- groups of the dyes and NH2 groups of the proteins.

Paper Details

Date Published: 17 June 1993
PDF: 7 pages
Proc. SPIE 1922, Laser Study of Macroscopic Biosystems, (17 June 1993); doi: 10.1117/12.146198
Show Author Affiliations
A. Elhaddaoui, Univ. of Science and Technology Lille (France)
A. Delacourte, INSERM (France)
S. Turrell, Univ. of Science and Technology Lille (France)

Published in SPIE Proceedings Vol. 1922:
Laser Study of Macroscopic Biosystems
Jouko E. Korppi-Tommola, Editor(s)

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