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Proceedings Paper

Vibrational Raman optical activity of proteins
Author(s): Steven J. Ford; L. D. Barron; A. Cooper; Lutz Hecht; Z. Q. Wen
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Paper Abstract

Recent advances in optical technology have led to the development, at Glasgow, Scotland of a backscattering incident circular polarization (ICP) Raman optical activity (ROA) instrument. The higher S/N ratio and the greater control of polarization artifacts has allowed the study of protein samples to become almost routine. The advantage of ROA, over conventional Raman, is the far more prominent stereochemical sensitivity. In the case of the Glasgow instrument ROA is achieved by measuring the small difference between the Raman intensities in incident circularly right polarized and circularly left polarized light. We hope to utilize this chiroptical extension of conventional Raman to gain new insights into protein conformation and dynamics.

Paper Details

Date Published: 17 June 1993
PDF: 5 pages
Proc. SPIE 1922, Laser Study of Macroscopic Biosystems, (17 June 1993); doi: 10.1117/12.146179
Show Author Affiliations
Steven J. Ford, Glasgow Univ. (United Kingdom)
L. D. Barron, Glasgow Univ. (United Kingdom)
A. Cooper, Glasgow Univ. (United Kingdom)
Lutz Hecht, Glasgow Univ. (United Kingdom)
Z. Q. Wen, Glasgow Univ. (United Kingdom)

Published in SPIE Proceedings Vol. 1922:
Laser Study of Macroscopic Biosystems
Jouko E. Korppi-Tommola, Editor(s)

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