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Proceedings Paper

On-line IR analyzer system to monitor cephamycin C loading on ion-exchange resin
Author(s): Sheldon Shank; Warren Russ; Douglas Gravatt; Wesley Lee; Steven M. Donahue
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Paper Abstract

An on-line infrared analyzer is being developed for monitoring cephamycin C loading on ion exchange resin. Accurate measurement of product loading offers productivity improvements with direct savings from product loss avoidance, minimized raw material cost, and reduced off-line laboratory testing. Ultrafiltered fermentation broth is fed onto ion exchange columns under conditions which adsorb the product, cephamycin C, to the resin while allowing impurities to pass unretained. Product loading is stopped when the on-line analyzer determines that resin capacity for adsorbing product is nearly exhausted. Infrared spectroscopy has been shown capable of quantifying cephamycin C in the process matrix at concentrations that support process control decisions. Process-to-analyzer interface challenges have been resolved, including sample conditioning requirements. Analyzer requirements have been defined. The sample conditioning station is under design.

Paper Details

Date Published: 14 August 1992
PDF: 7 pages
Proc. SPIE 1681, Optically Based Methods for Process Analysis, (14 August 1992); doi: 10.1117/12.137755
Show Author Affiliations
Sheldon Shank, Merck Manufacturing Div. (United States)
Warren Russ, Merck Manufacturing Div. (United States)
Douglas Gravatt, Merck Manufacturing Div. (United States)
Wesley Lee, Merck Manufacturing Div. (United States)
Steven M. Donahue, Spectra-Tech Applied Systems, Inc. (United States)

Published in SPIE Proceedings Vol. 1681:
Optically Based Methods for Process Analysis
David S. Bomse; Harry Brittain; Stuart Farquharson; Jeremy M. Lerner; Alan J. Rein; Cary Sohl; Terry R. Todd; Lois Weyer, Editor(s)

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