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Proceedings Paper

Photosensitized inactivation of infectious agents for sterilization of red blood cell concentrates and whole blood
Author(s): Millard M. Judy; James Lester Matthews; Franklin M. Sogandares-Bernal; Joseph T. Newman; Tran C. Chanh; Alain J. Marengo-Rowe
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Paper Abstract

More than 10 million units of human blood components are transfused annually in the United States. Although donor screening and testing have greatly lowered the risk of transmission of viral and protozoan infectious agents, additional sterilization procedures which also preserve blood component function would be of significant value. Use of visible-light-range photosensitizers for sterilization of red blood cells is currently being aggressively investigated in laboratory-scale optical-mechanical systems. Both the photochemical sterilization process and the optical-mechanical system must operate without introducing significant alteration in the properties of the red cells. With successful demonstration of the efficacy and safety of these sterilization techniques, implementation in the blood bank setting will require scale-up to optical-mechanical systems capable of handling approximately 50,000 units daily in 500 - 1,000 blood banks in the United States.

Paper Details

Date Published: 1 June 1992
PDF: 5 pages
Proc. SPIE 1650, Medical Lasers and Systems, (1 June 1992); doi: 10.1117/12.137507
Show Author Affiliations
Millard M. Judy, Baylor Univ. Medical Ctr. (United States)
James Lester Matthews, Baylor Univ. Medical Ctr. (United States)
Franklin M. Sogandares-Bernal, Baylor Univ. Medical Ctr. (United States)
Joseph T. Newman, Baylor Univ. Medical Ctr. (United States)
Tran C. Chanh, Southwest Foundation for Biomedical Research (United States)
Alain J. Marengo-Rowe, Baylor Univ. Medical Ctr. (United States)

Published in SPIE Proceedings Vol. 1650:
Medical Lasers and Systems
David M. Harris; Stuart D. Harman, Editor(s)

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