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Proceedings Paper

Monitoring photochemistry in tissue using frequency domain photon migration
Author(s): Tsong-Tseh Tsay; Bruce J. Tromberg; Eric H. Cho; Khai T. Vu; Lars Othar Svaasand
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Paper Abstract

Frequency domain photon migration (FDPM) non-invasively investigates the optical properties of multiple-scattering media such as tissue. In this work, FDPM is used to examine the optical properties of an EMT-6 murine tumor model in Balb/c mice. In-vivo measurements are recorded before and after intravenous administration of the photosensitizer, chloroaluminum tetra-sulfonated phthalocyanine (CASPc). Optical properties are used to: (1) discriminate between tumor and healthy tissue and (2) monitor the rate of tumor drug uptake. Our data show substantial frequency-dependent contrast between tumor and normal tissue. In addition, drug pharmacokinetics are effectively recorded in situ. Although FDPM can quantitatively measure absorption and scattering coefficients in infinite homogeneous media, exact values of these optical properties are difficult to extract in vivo due to boundary condition uncertainties.

Paper Details

Date Published: 7 August 1992
PDF: 6 pages
Proc. SPIE 1646, Laser-Tissue Interaction III, (7 August 1992); doi: 10.1117/12.137461
Show Author Affiliations
Tsong-Tseh Tsay, Beckman Laser Institute and Medical Clinic (United States)
Bruce J. Tromberg, Beckman Laser Institute and Medical Clinic (United States)
Eric H. Cho, Beckman Laser Institute and Medical Clinic (United States)
Khai T. Vu, Beckman Laser Institute and Medical Clinic (United States)
Lars Othar Svaasand, Univ. of Trondheim (Norway)

Published in SPIE Proceedings Vol. 1646:
Laser-Tissue Interaction III
Steven L. Jacques, Editor(s)

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