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Proceedings Paper

Acute effects of pulsed-laser irradiation on the arterial wall
Author(s): Fumitaka Nakamura M.D.; Jan Kvasnicka; Hanjiang Lu; Herbert J. Geschwind M.D.; Micheline Levame; Hassan Bousbaa; Francoise Lange
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Paper Abstract

Pulsed laser coronary angioplasty with an excimer or a holmium-yttrium-aluminum-garnet (Ho:YAG) laser may become an alternative treatment for patients with coronary artery disease. However, little is known about its acute consequences on the normal arterial wall. This study was designed to examine the acute histologic consequences of these two pulsed lasers on the arterial wall of normal iliac arteries in rabbits. Irradiation with each laser was performed in 15 normal iliac sites on eight male New Zealand white rabbits. The excimer laser was operated at 308 nm, 25 Hz, 50 mJ/mm2/pulse, and 135 nsec/pulse and the Ho:YAG laser was operated at 2.1 micrometers , 3/5 Hz, 400 mJ/pulse, and 250 microsecond(s) ec/pulse. The excimer and Ho:YAG laser were coupled into a multifiber wire-guided catheter of 1.4 and 1.5 mm diameter, respectively. The sites irradiated with excimer or Ho:YAG laser had the same kinds of histologic features, consisting of exfoliation of the endothelium, disorganization of internal elastic lamina, localized necrosis of vascular smooth muscle cells, and fissures in the medial layer. However, the sites irradiated with excimer laser had lower grading scores than those irradiated with Ho:YAG laser (p < 0.05). Laser irradiation with excimer or Ho:YAG laser of normal arteries results in localized mechanical vascular injury.

Paper Details

Date Published: 28 August 1992
PDF: 6 pages
Proc. SPIE 1642, Diagnostic and Therapeutic Cardiovascular Interventions II, (28 August 1992);
Show Author Affiliations
Fumitaka Nakamura M.D., Univ. Hopital Henri Mondor (France)
Jan Kvasnicka, Univ. Hopital Henri Mondor (France)
Hanjiang Lu, Univ. Hopital Henri Mondor (France)
Herbert J. Geschwind M.D., Univ. Hopital Henri Mondor (France)
Micheline Levame, Univ. Hopital Henri Mondor (France)
Hassan Bousbaa, Univ. Hopital Henri Mondor (France)
Francoise Lange, Univ. Hopital Henri Mondor (France)

Published in SPIE Proceedings Vol. 1642:
Diagnostic and Therapeutic Cardiovascular Interventions II
George S. Abela M.D., Editor(s)

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