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Proceedings Paper

Recent progress with atomic-force microscopy in biology: molecular resolution imaging of cell membranes, constituent biomolecules, and microcrystals
Author(s): Morton F. Arnsdorf M.D.; Ratneshwar Lal
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Paper Abstract

Atomic force microscopy (AFM) holds great promise for biological research in that it permits: (1) the imaging of membranes and biomolecules of interest with subnanometer resolution in a physiologic environment and (2) the physical manipulation of biomolecules at nanometer scale (nanotechnology). We summarize our recent successful experience with the molecular resolution of hepatic and cardiac gap junctions, porin channels, and organic microcrystals; and with the physical manipulation of gap junction membranes using the AFM cantilever. AFM may revolutionize our approach to the study of structure-activity and perhaps structure- function in many areas of biological research.

Paper Details

Date Published: 1 August 1992
PDF: 5 pages
Proc. SPIE 1778, Imaging Technologies and Applications, (1 August 1992); doi: 10.1117/12.130966
Show Author Affiliations
Morton F. Arnsdorf M.D., Univ. of Chicago (United States)
Ratneshwar Lal, Univ. of Chicago (United States)

Published in SPIE Proceedings Vol. 1778:
Imaging Technologies and Applications
Robert J. Heaston, Editor(s)

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