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Journal of Biomedical Optics • Open Access

Calibration of diffuse correlation spectroscopy blood flow index with venous-occlusion diffuse optical spectroscopy in skeletal muscle
Author(s): Zhe Li; Wesley B. Baker; Ashwin B. Parthasarathy; Tiffany S. Ko; Detian Wang; Steven Schenkel; Turgut Durduran; Gang Li; Arjun G. Yodh

Paper Abstract

We investigate and assess the utility of a simple scheme for continuous absolute blood flow monitoring based on diffuse correlation spectroscopy (DCS). The scheme calibrates DCS using venous-occlusion diffuse optical spectroscopy (VO-DOS) measurements of arm muscle tissue at a single time-point. A calibration coefficient (γ) for the arm is determined, permitting conversion of DCS blood flow indices to absolute blood flow units, and a study of healthy adults (N=10) is carried out to ascertain the variability of γ. The average DCS calibration coefficient for the right (i.e., dominant) arm was γ=(1.24±0.15)×108 (mL·100  mL−1·min−1)/(cm2/s). However, variability can be significant and is apparent in our site-to-site and day-to-day repeated measurements. The peak hyperemic blood flow overshoot relative to baseline resting flow was also studied following arm-cuff ischemia; excellent agreement between VO-DOS and DCS was found (R2=0.95, slope=0.94±0.07, mean difference=−0.10±0.45). Finally, we show that incorporation of subject-specific absolute optical properties significantly improves blood flow calibration accuracy.

Paper Details

Date Published: 23 December 2015
PDF: 14 pages
J. Biomed. Opt. 20(12) 125005 doi: 10.1117/1.JBO.20.12.125005
Published in: Journal of Biomedical Optics Volume 20, Issue 12
Show Author Affiliations
Zhe Li, Univ. of Pennsylvania (United States)
Tianjin Univ. (China)
Wesley B. Baker, Univ. of Pennsylvania (United States)
Ashwin B. Parthasarathy, Univ. of Pennsylvania (United States)
Tiffany S. Ko, Univ. of Pennsylvania (United States)
Detian Wang, Univ. of Pennsylvania (United States)
Institute of Fluid Physics (China)
Steven Schenkel, Univ. of Pennsylvania (United States)
Turgut Durduran, ICFO - Institut de Ciències Fotòniques (Spain)
Gang Li, Tianjin Univ. (China)
Arjun G. Yodh, Univ. of Pennsylvania (United States)

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