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Spie Press Book

Optical Gas Sensors for Exhaled Breath Analysis
Author(s): Paula R. Fortes; João F.S. Petruci; Ivo M. Raimundo Jr.
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Book Description

This Spotlight discusses optical sensing strategies and applications for early diagnostics in exhaled breath (EB) analyses. These sensors can noninvasively assess relevant biomarkers in EB, enabling early diagnosis of several diseases (e.g., cancer, asthma, diabetes) and the monitoring of breath metabolites in hospitalized patients after drug administration. Gas sensors with suitable selectivity, sensitivity, and a short response time are essential; in particular, optical-sensor-based transductions (e.g., UV-Vis absorbance, luminescence, infrared) are ideal for building portable dedicated devices, such as lab-on-a-chip and microfluidics devices.

Book Details

Date Published: 1 August 2017
Pages: 40
ISBN: 9781510613782
Volume: SL33

Table of Contents
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1 Introduction

2 State of the Art and Challenges

3 Optical Sensors and Strategies for Exhaled Breath Analysis
3.1 Colorimetric sensor arrays
3.2 Optical absorption spectroscopy
     3.2.1 Infrared laser absorption spectroscopy
     3.2.2 Cavity ringdown spectroscopy
     3.2.3 Integrated cavity output spectroscopy
     3.2.4 Photoacoustic spectroscopy
     3.2.5 Laser absorption spectroscopy in exhaled breath analysis
3.3 Optical sensors based on Raman spectroscopy
3.4 Luminescence sensors
3.5 Strategies for point-of-care devices

4 Current Market and Perspectives

5 Conclusions and Outlook



Since Paracelsus in the late medieval ages, the analysis of exhaled breath has served to determine the health condition of patients. Steady progress in analytical instrumentation and, more recently, sensing technologies has translated qualitative odor diagnostics into precise and reliable tools ready for clinical usage, providing quantitative molecular information. Despite the complexity of the exhaled breath matrix, diseases as well as therapeutically relevant biomarker panels are readily accessible in a noninvasive fashion to provide insight into the physiological condition of the patient, disease status, and therapeutic progress. Recent progress in optics, photonics, and system miniaturization and integration has given optical sensors the potential to lead the field of breath analysis into routinely applied and, ultimately, low-cost diagnostics for point-of-care application scenarios.

Paula Regina Fortes
Joao Flavio da Silveira Petruci
Ivo Milton Raimundo, Jr.
July 2017

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