The Moscone Center
San Francisco, California, United States
1 - 6 February 2020
Conference 11222
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Molecular-Guided Surgery: Molecules, Devices, and Applications VI
Saturday - Sunday 1 - 2 February 2020
Conference Sessions
At A Glance
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1: Advanced Detection Methods I
2: Advanced Detection Methods II
3: Imaging Systems
BiOS Hot Topics
4: Contrast Agents
5: Clinical Translation and Clinical Applications I
6: Clinical Translation and Clinical Applications II
7: Clinical Translation and Clinical Applications III
Posters-Sunday
BiOS Sunday Plenary
Important
Dates
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Abstract Due:
24 July 2019

Author Notification:
30 September 2019

Manuscript Due Date:
8 January 2020

Conference
Cosponsors
Sponsored by:










Conference
Committee
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Conference Chairs
Conference Co-Chair
  • Brian W. Pogue, Thayer School of Engineering at Dartmouth (United States)

Program Committee
Program Committee continued...
Saturday 1 February Show All Abstracts
Session 1:
Advanced Detection Methods I
Saturday 1 February 2020
10:00 AM - 12:00 PM
Location: Room 76 (Lower Mezzanine South)
Session Chairs:
Frédéric Leblond, Polytechnique Montréal (Canada) ;
Summer L. Gibbs, Oregon Health & Science Univ. (United States)
Quantitative assessment of lower limb circulation with non-invasive optical imaging (Invited Paper)
Paper 11222-1
Time: 10:00 AM - 10:30 AM
Author(s): Amaan Mazhar, Modulim (United States)
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Generative adversarial network prediction of optical properties from wide-field images (Invited Paper)
Paper 11222-2
Time: 10:30 AM - 11:00 AM
Author(s): Nicholas J. Durr, Johns Hopkins Univ. (United States)
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Combined structural and molecular imaging using optical coherence tomography and immunofluorescence imaging
Paper 11222-3
Time: 11:00 AM - 11:20 AM
Author(s): Fabio Feroldi, Margherita Vaselli, Vrije Univ. Amsterdam (Netherlands); Mariska Verlaan, Amsterdam UMC (Netherlands); Helene Knaus, Valentina Davidoiu, Vrije Univ. Amsterdam (Netherlands); Danielle Vugts, Carla Molthoff, Guus van Dongen, Amsterdam UMC (Netherlands); Johannes F. de Boer, Vrije Univ. Amsterdam (Netherlands)
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Rapid assessment of skin surgical margins using superpixel Raman spectroscopic imaging
Paper 11222-5
Time: 11:20 AM - 11:40 AM
Author(s): Xu Feng, Matthew C. Fox, Jason S. Reichenberg, Fabiana C. P. S. Lopes, Katherine R. Sebastian, Andrew K. Dunn, Mia K. Markey, James W. Tunnell, The Univ. of Texas at Austin (United States)
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One hundred percent successful automatic breast cancer diagnosis using static and dynamic FFOCT images
Paper 11222-4
Time: 11:40 AM - 12:00 PM
Author(s): Jules Scholler, Olivier Thouvenin, Institut Langevin Ondes et Images (France); Emilie Benoit a la Guillaume, LLTech SAS (France); Claude Boccara, Institut Langevin Ondes et Images (France)
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Lunch/Exhibition 12:00 PM - 1:30 PM
Session 2:
Advanced Detection Methods II
Saturday 1 February 2020
1:30 PM - 3:00 PM
Location: Room 76 (Lower Mezzanine South)
Session Chairs:
Alexander L. Antaris, Intuitive Surgical, Inc. (United States) ;
Amaan Mazhar, Modulim (United States)
Augmenting the vision of the endoscopist: seeing cancer in a new light (Invited Paper)
Paper 11222-6
Time: 1:30 PM - 2:00 PM
Author(s): Sarah E. Bohndiek, Univ. of Cambridge (United Kingdom)
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Affinity-based color enhancement methods for contrast enhancement in hyperspectral and multimodal imaging
Paper 11222-7
Time: 2:00 PM - 2:20 PM
Author(s): Arturo Pardo, José A. Gutiérrez-Gutiérrez, Univ. de Cantabria (Spain), Instituto de Investigación Valdecilla (IDIVAL) (Spain); José M. López-Higuera, Univ. de Cantabria (Spain), Instituto de Investigación Valdecilla (IDIVAL) (Spain), CIBER-BBN (Spain); Brian W. Pogue, Thayer School of Engineering at Dartmouth (United States); Olga M. Conde, Univ. de Cantabria (Spain), Instituto de Investigación Valdecilla (IDIVAL) (Spain), CIBER-BBN (Spain)
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Real-time, quantitative and wide-field oxygenation imaging platform for surgery
Paper 11222-8
Time: 2:20 PM - 2:40 PM
Author(s): Enagnon Aguénounon, Silvère Ségaud, Henrique Waxin, Lucile Zorn, Julien Lamy, Murielle Torregrossa, Joseph Angelo, Sylvain Gioux, ICube (France)
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A backside-illuminated low-noise multispectral imager for near-infrared fluorescence image-guided surgery
Paper 11222-9
Time: 2:40 PM - 3:00 PM
Author(s): Steven M. Blair, Amit Deliwala, Eric Chen, Sailesh Subashbabu, Anthony Li, Mebin George, Missael Garcia, Univ. of Illinois (United States); Nan Cui, Washington Univ. in St. Louis (United States); Viktor Gruev, Univ. of Illinois (United States)
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Coffee Break 3:00 PM - 3:30 PM
Session 3:
Imaging Systems
Saturday 1 February 2020
3:30 PM - 5:40 PM
Location: Room 76 (Lower Mezzanine South)
Session Chairs:
Sarah E. Elizabeth Bohndiek, Univ. of Cambridge (United Kingdom) ;
Nicholas J. Durr, Johns Hopkins Univ. (United States)
Imaging the cellular microenvironment in surgical wounds (Invited Paper)
Paper 11222-10
Time: 3:30 PM - 4:00 PM
Author(s): Kevin W. Eliceiri, Univ. of Wisconsin-Madison (United States)
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Fluorescence headlights proposed for minimally-invasive surgical tools (Invited Paper)
Paper 11222-11
Time: 4:00 PM - 4:20 PM
Author(s): Eric J. Seibel, Univ. of Washington (United States)
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Indocyanine-green matching phantom for fluorescence-guided imaging system characterization and performance monitoring
Paper 11222-12
Time: 4:20 PM - 4:40 PM
Author(s): Alberto J. Ruiz, Thayer School of Engineering at Dartmouth (United States); Mindy Wu, Duke Univ. (United States); Ethan P. M. LaRochelle, Thayer School of Engineering at Dartmouth (United States); Dimitris Gorpas, Technische Univ. München (Germany); Joshua Pfefer, U.S. Food and Drug Administration (United States); Vasilis Ntziachristos, Technische Univ. München (Germany); Brian W. Pogue, Thayer School of Engineering at Dartmouth (United States)
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Image-guided fluorescence tomography in tissue phantom models of oral cancer
Paper 11222-13
Time: 4:40 PM - 5:00 PM
Author(s): Michael J. Daly, Harley Chan, Univ. Health Network (Canada); Marco Ferrari, Univ. degli Studi di Brescia (Italy); Catriona Douglas, Jacqueline Fleisig, Brian C. Wilson, David A. Jaffray, Jonathan C. Irish, Univ. Health Network (Canada)
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Endosteal and periosteal blood flow quantified with dynamic contrast-enhanced fluorescence to guide open orthopaedic surgery
Paper 11222-14
Time: 5:00 PM - 5:20 PM
Author(s): Shudong Jiang, Thayer School of Engineering at Dartmouth (United States); Jonathan T. Elliott, Dartmouth-Hitchcock Medical Ctr. (United States); Jason R. Gunn, Thayer School of Engineering at Dartmouth (United States); Cao Xu, Dartmouth College (United States); Alberto J. Ruiz, Brian W. Pogue, Thayer School of Engineering at Dartmouth (United States); Eric R. Henderson, Ida Leah Gitajn, Dartmouth-Hitchcock Medical Ctr. (United States)
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Fluorescence lifetime-based tumor contrast enhancement using targeted near infrared probes
Paper 11222-15
Time: 5:20 PM - 5:40 PM
Author(s): Rahul Pal, Anand T. Kumar, Massachusetts General Hospital (United States)
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Session HT:
BiOS Hot Topics
Saturday 1 February 2020
7:00 PM - 9:00 PM
Location: Room 206/214 (South Level Two)

The full list of Hot Topics speaker can be found online at https://spie.org/PWB/special-events/Plenary-Event
Sunday 2 February Show All Abstracts
Session 4:
Contrast Agents
Sunday 2 February 2020
8:30 AM - 10:00 AM
Location: Room 76 (Lower Mezzanine South)
Session Chairs:
Kimberley S. Samkoe, Dartmouth-Hitchcock Medical Ctr. (United States) ;
Conor L. Evans, Wellman Ctr. for Photomedicine (United States)
Nanotechnology platforms for precision theranostics: deconvoluting the specificity puzzle with quantitative molecular imaging (Invited Paper)
Paper 11222-16
Time: 8:30 AM - 9:00 AM
Author(s): Girgis Obaid, Wellman Ctr. for Photomedicine (United States)
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In vivo nerve-specificity of rhodamines and Si-rhodamines
Paper 11222-17
Time: 9:00 AM - 9:20 AM
Author(s): Antonio R. Montaño, Lei G. Wang, Connor W. Barth, Nourhan A. Shams, K. A. Sashini U. Kumarapeli, Summer L. Gibbs, Oregon Health & Science Univ. (United States)
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Fluorescence image-guided surgery: a perspective on contrast agent development
Paper 11222-18
Time: 9:20 AM - 9:40 AM
Author(s): Connor W. Barth, Summer Gibbs, Oregon Health & Science Univ. (United States)
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Fluorescence imaging contrast in guided surgery on nerves measured in rats in vivo
Paper 11222-19
Time: 9:40 AM - 10:00 AM
Author(s): Félix Fanjul-Vélez, Univ. de Cantabria (Spain); Álvaro M. Díaz-Martínez, Univ. de Cantabria (Spain), Ctr. de Investigación Biomédica en Red de Salud Mental (Spain), Instituto de Biomedicina y Biotecnologia de Cantabria (Spain); Emilio Garro-Martínez, Univ. de Cantabria (Spain), Ctr. de Investigación Biomédica en Red de Salud Mental (Spain); José L. Arce-Diego, Univ. de Cantabria (Spain)
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Coffee Break 10:00 AM - 10:30 AM
Session 5:
Clinical Translation and Clinical Applications I
Sunday 2 February 2020
10:30 AM - 12:30 PM
Location: Room 76 (Lower Mezzanine South)
Session Chairs:
Kenneth M. Tichauer, Illinois Institute of Technology (United States) ;
Summer L. Gibbs, Oregon Health & Science Univ. (United States)
Antibodies, favorite tools for fluorescence-guided surgery (Invited Paper)
Paper 11222-20
Time: 10:30 AM - 11:00 AM
Author(s): André Pèlegrin, Institut de Recherche en Cancérologie de Montpellier (France); Marian Gutowski, Institut Regional du Cancer de Montpellier (France); Françoise Cailler, SurgiMab (France)
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MUC16 as a potential target for the surgical detection of pancreatic cancer (Invited Paper)
Paper 11222-21
Time: 11:00 AM - 11:30 AM
Author(s): Madeline T. Olson, Nicholas E. Wojtynek, Thomas C. Caffrey, Prakash Radhakrishnan, Quan P. Ly, Geoffrey A. Talmon, Michael A. Hollingsworth, Aaron M. Mohs, Univ. of Nebraska Medical Ctr. (United States)
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Tumor margin assessment using frozen sections can be improved by paired-agent imaging
Paper 11222-22
Time: 11:30 AM - 11:50 AM
Author(s): Kimberley S. Samkoe, Dartmouth-Hitchcock Medical Ctr. (United States); Cheng Wang, Thayer School of Engineering at Dartmouth (United States); Eunice Chen, Laura Tafe, Dartmouth-Hitchcock Medical Ctr. (United States); Kenneth Tichauer, Illinois Institute of Technology (United States)
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Task-based evaluation of fluorescent-guided cancer surgery as a means of identifying optimal imaging agent properties in the context of variability in tumor- and healthy-tissue physiology
Paper 11222-23
Time: 11:50 AM - 12:10 PM
Author(s): Kenneth M. Tichauer, Illinois Institute of Technology (United States); Cheng Wang, Thayer School of Engineering at Dartmouth (United States); Xiaochun Xu, Kimberley S. Samkoe, Dartmouth College (United States)
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A proof-of-concept methodology to validate the in situ visualization of residual disease using cancer-targeted molecular agents in fluorescence-guided surgery
Paper 11222-24
Time: 12:10 PM - 12:30 PM
Author(s): Servando Hernandez Vargas, Institute of Molecular Medicine, The Univ. of Texas Health Science Ctr. at Houston (United States); Christie Lin, OnLume, Inc. (United States); Solmaz Agha Amiri, Julie Voss, Institute of Molecular Medicine, The Univ. of Texas Health Science Ctr. at Houston (United States); Naru Ikoma, Hop S. Tran Cao, The Univ. of Texas M. D. Anderson Cancer Ctr. (United States); Sukhen C. Ghosh, The Univ. of Texas Health Science Ctr. at Houston (United States); Adam Uselmann, OnLume, Inc. (United States); Ali Azhdarinia, Institute of Molecular Medicine, The Univ. of Texas Health Science Ctr. at Houston (United States)
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Lunch/Exhibition Break 12:30 AM - 1:30 AM
Session 6:
Clinical Translation and Clinical Applications II
Sunday 2 February 2020
1:30 PM - 3:10 PM
Location: Room 76 (Lower Mezzanine South)
Session Chairs:
Sylvain Gioux, Lab. des sciences de l'Ingénieur, de l'Informatique et de l'Imagerie (France) ;
Brian W. Pogue, Thayer School of Engineering at Dartmouth (United States)
The clinical translation of a near-infrared fluorophore for fluorescence guided surgery: SGM-101 from the lab to a phase III trial (Invited Paper)
Paper 11222-30
Time: 1:30 PM - 2:00 PM
Author(s): Ruben P. Meijer, Kim S. Valk, Leiden University Medical Center (Netherlands), Centre for Human Drug Research (Netherlands); Bérénice Framery, SurgiMab (France); Marian Gutowski, Institut du Cancer de Montpellier (France); André Pèlegrin, Institut de Recherche en Cancérologie de Montpellier (France); Françoise Cailler, SurgiMab (France); Denise E. Hilling, Alexander L. Vahrmeijer, Leiden University Medical Center (Netherlands)
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Optical imaging devices and optical imaging agents: a device maker’s observations (Invited Paper)
Paper 11222-26
Time: 2:00 PM - 2:30 PM
Author(s): John Fengler, Stryker Endoscopy (United States)
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Update on AAPM task group 311: guidance for technical performance evaluation for fluorescence guided surgery systems
Paper 11222-27
Time: 2:30 PM - 2:50 PM
Author(s): Brian W. Pogue, Thayer School of Engineering at Dartmouth (United States); Timothy Zhu, Univ. of Pennsylvania (United States); Vasilis Ntziachristos, Helmholtz Zentrum München GmbH (Germany); Brian C. Wilson, Univ. of Toronto (Canada); Keith D. Paulsen, Thayer School of Engineering at Dartmouth (United States); Sylvain Gioux, Univ. de Strasbourg (France); Robert Nordstrom, National Cancer Institute (United States); Joshua Pfefer, U.S. Food and Drug Administration (United States); Bruce J. Tromberg, National Institute of Biomedical Imaging and Bioengineering (United States); Heidrun Wabnitz, Physikalisch-Technische Bundesanstalt (Germany); Arjun Yodh, Univ. of Pennsylvania (United States); Yu Chen, Univ. of Maryland, Baltimore County (United States); Maritoni Litorja, National Institute of Standards and Technology (United States)
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First short-wave infrared (SWIR) fluorescence imaging in humans: imaging of ABY-029 in head and neck cancers
Paper 11222-28
Time: 2:50 PM - 3:10 PM
Author(s): Brook K. Byrd, Dartmouth College (United States); Joseph A. Paydarfar, Dennis J. Wirth, Laura J. Tafe, Kimberely S. Samkoe, Dartmouth-Hitchcock Medical Ctr. (United States); Keith D. Paulsen, Scott C. Davis, Thayer School of Engineering at Dartmouth (United States)
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Coffee Break 3:10 PM - 3:40 PM
Session 7:
Clinical Translation and Clinical Applications III
Sunday 2 February 2020
3:40 PM - 5:40 PM
Location: Room 76 (Lower Mezzanine South)
Session Chairs:
Sylvain Gioux, Lab. des sciences de l'Ingénieur, de l'Informatique et de l'Imagerie (France) ;
Brian W. Pogue, Thayer School of Engineering at Dartmouth (United States)
Optical imaging, surgery and drug development: a successful triangle (Invited Paper)
Paper 11222-29
Time: 3:40 PM - 4:10 PM
Author(s): Gooitzen M. van Dam, Univ. Medical Ctr. Groningen (Netherlands)
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Clinical application of fluorescence in the operating room (Invited Paper)
Paper 11222-25
Time: 4:10 PM - 4:40 PM
Author(s): Eben L. Rosenthal, Stanford Univ. School of Medicine (United States)
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Near infrared fluorescence-guided surgery in pancreatic cancers
Paper 11222-31
Time: 4:40 PM - 5:00 PM
Author(s): Guolan Lu, Nynke van den Berg, Brock Martin, Zachary Hart, Naoki Nishio, Stan van Keulen, Shayan Fakurnejad, Quan Zhou, Stefania Chirita, George Fisher, George Poultsides, Eben Rosenthal, Stanford Univ. (United States)
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Perspectives on the phase 0 clinical trial of microdose administration of ABY-029 for fluorescence guided surgery: Stability testing
Paper 11222-32
Time: 5:00 PM - 5:20 PM
Author(s): Kimberley S. Samkoe, Dartmouth-Hitchcock Medical Ctr. (United States); Sally Hull, Thayer School of Engineering at Dartmouth (United States); Jonathan Elliott, Dartmouth-Hitchcock Medical Ctr. (United States); Hira Shahzad Sardar, Jason Gunn, Thayer School of Engineering at Dartmouth (United States); Konstantinos Linos, Laura Tafe, Dartmouth-Hitchcock Medical Ctr. (United States); Brent Harris, Georgetown University Medical Center (United States); Joachim Feldwisch, Affibody AB (Sweden); Brian Pogue, Thayer School of Engineering at Dartmouth (United States); David Roberts, Eric Henderson, Joseph Paydarfar, Dartmouth-Hitchcock Medical Ctr. (United States); Keith Paulsen, Thayer School of Engineering at Dartmouth (United States)
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Effect of preoperative cancer treatment on epidermal growth factor receptor (EGFR) receptor expression level in ABY-029 guided sarcoma surgery
Paper 11222-33
Time: 5:20 PM - 5:40 PM
Author(s): Xiaochun Xu, Dartmouth-Hitchcock Medical Ctr. (United States); Kimberley Samkoe, Dartmouth College (United States), Dartmouth-Hitchcock Medical Ctr. (United States); Eric Henderson, Dartmouth-Hitchcock Medical Ctr. (United States)
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Session PSun:
Posters-Sunday
Sunday 2 February 2020
5:30 PM - 7:00 PM
Location: Moscone Center, Level 3 West

Conference attendees are invited to attend the BiOS poster session on Sunday evening. Come view the posters, enjoy light refreshments, ask questions, and network with colleagues in your field. Authors of poster papers will be present to answer questions concerning their papers. Attendees are required to wear their conference registration badges to the poster sessions. Poster authors, view poster presentation guidelines and set-up instructions at [{http://spie.org/PWPosterGuidelines}+{http://spie.org/PWPosterGuidelines}].
Pharmacokinetic fluorescence imaging of for comparative uptake of therapeutics in an open skin murine model
Paper 11222-34
Time: 5:30 PM - 7:00 PM
Author(s): Jason R. Gunn, Ethan Philip M. LaRochelle, Thayer School of Engineering at Dartmouth (United States); Kimberley S. Samkoe, Dartmouth-Hitchcock Medical Ctr. (United States); Brian W. Pogue, Thayer School of Engineering at Dartmouth (United States)
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Session PLN:
BiOS Sunday Plenary
Sunday 2 February 2020
7:15 PM - 8:00 PM
Location: Room 206/214 (South Level Two)
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